肿瘤相关巨噬细胞和MMP-2在成釉细胞瘤中的表达及意义  

Expression and clinical significance of tumor-associated macrophages and matrix metalloproteinase-2 in ameloblastomas

作　　者：孙福星[1] 范亚伟[2] 

机构地区：[1]山西医科大学,山西太原030001 [2]山西医科大学第一医院口腔科,山西太原030001

出　　处：《口腔生物医学》2016年第2期76-78,共3页Oral Biomedicine

摘　　要：目的:探讨肿瘤相关巨噬细胞(TAMs)和基质金属蛋白酶-2(MMP-2)在人成釉细胞瘤(ABs)中的表达及意义。方法:采用免疫组化通用二步法,分别检测43例ABs和10例正常口腔黏膜中CD68标记的巨噬细胞数目及MMP-2的表达情况。结果:TAMs和MMP-2在ABs中的表达均高于正常黏膜,差异有统计学意义(P<0.01)。在ABs中,TAMs主要表达于肿瘤间质,MMP-2主要表达于肿瘤实质,MMP-2表达强度随着TAMs计数增加而增加,二者呈正相关关系(r=0.331,P<0.05)。结论:ABs中TAMs和MMP-2的共同表达可能在其发生发展中发挥重要作用。Objective：To investigate the expression and clinical significance of tumor-associated macrophages（TAMs） and matrix metalloproteinase-2（ MMP-2） in ameloblastomas（ ABs） . Methods：The expression of TAMs（ CD68） and MMP-2 was examined in 43 ABs and 10 normal oral mucosa by universal two-step immunohistochemical technique. Results：Expression of TAMs and MMP-2 were significantly higher in ABs compared with normal oral mucosa（P〈0.01）. TAMs was mainly expressed within the stroma and MMP-2 was mainly expressed within the islands of ABs. There was a positive correlation between MMP-2 score and TAMs count in ABs（ r=0.331, P〈0.05） . Conclusions：The common expression of TAMs and MMP-2 may play an important role in the development of ABs.

关 键 词：成釉细胞瘤 肿瘤相关巨噬细胞 基质金属蛋白酶-2 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]