骨髓浸润非霍奇金淋巴瘤患者中TEL重排表达及意义  

Expression and significance of TEL rearrangement in non Hodgkin lymphoma with bone marrow infiltration

作　　者：高娜[1] 郭农建[2] 于文征[1] 王学霞[1] 孙建荣[1] 刘增艳[1] 刘仁同[1] 刘晓丹[1] 

机构地区：[1]滨州医学院附属医院血液内科,256603 [2]山东大学附属济南市中心医院血液内科,250013

出　　处：《实用医学杂志》2016年第9期1437-1439,共3页The Journal of Practical Medicine

基　　金：滨州医学院校级科研计划项目(编号:BY2013KJ38)

摘　　要：目的:检测非霍奇金淋巴瘤(NHL)中TEL重排的表达,探讨TEL重排与伴骨髓浸润NHL临床特征、实验室检查及疗效的关系。方法:收集163例(伴骨髓浸润者38例,不伴骨髓浸润者125例)NHL骨髓,应用Split-FSIH技术检测TEL重排,依据结果将伴骨髓浸润NHL分为阳性组和阴性组,比较两组初诊时临床特征、实验室检查及疗效。结果:163例NHL中,TEL重排总检出率为3.68%,其中38例伴骨髓浸润NHL中,TEL重排检出率为13.2%,其余患者为0.8%,两者比较差异有统计学意义;TEL重排与年龄、白细胞数、血清LDH水平相关,而与性别、B症状、肝脾及淋巴结肿大、细胞来源、血红蛋白水平、血小板计数无关。5例重排阳性者,1例化疗有效,中位生存期3个月,33例重排阴性者,除2例放弃治疗外,23例化疗有效,中位生存期15个月。结论 :TEL重排阳性者易合并骨髓侵犯,此类患者侵袭性更高,预后更差。Objective To detect the expression of TEL rearangement in non Hodgkin＇s lymphoma（NHL）patients, and to investigate the relationship between TEL rearrangement and clinical characteristics, laboratory examination and efficacy of NHL with bone marrow（BM） infiltration. Methods TEL rearrangement was detected by Split-FSIH in 163 NHL（38 with BM invasion, 125 without BM infiltration）, while the NHL with BM infiltration were divided into positive and negative group according to the test. The clinical characteristics,laboratory examination and efficacy between the two groups were compared with each other by retrospective analysis. Results TEL rearrangement were detected in 6 of 163 NHL（3.68%）, in 5 of 38 NHL with BM infiltration（13.2%）, but in 1 of 125 NHL without BM infiltration（0.8%）. The comparison was statistically significant. TEL rearrangement was related with age, WBC, LDH levels, but not related with sex, B symptoms,hepatosplenomegaly or lymphadenopathy, cell source, HGB, PLT. Conclusion NHL with TEL rearrangement may have more liability with BM invasion and show more aggressive clinical course and worse prognosis.

关 键 词：非霍奇金淋巴瘤 骨髓浸润 TEL基因 预后 

分 类 号：R733.1[医药卫生—肿瘤]