非霍奇金淋巴瘤患者乙型肝炎病毒感染情况分析  

Analysis of hepatitis B virus infection status in patients with non-Hodgkin lymphoma

作　　者：舒媚 陈文虎[2] 吴振兴[2] 邵卓 刘小香[2] 

机构地区：[1]永康市中医院,浙江永康321300 [2]杭州医学院,浙江杭州310053

出　　处：《中国卫生检验杂志》2016年第9期1276-1277,1280,共3页Chinese Journal of Health Laboratory Technology

基　　金：第二批浙江省医学创新学科建设计划([2015]13);浙江省医学高等专科学校重点学科持续建设计划(2013XKCX03)

摘　　要：目的研究非霍奇金淋巴瘤(NHL)患者中乙型肝炎病毒(HBV)的感染率。方法回顾性分析2009年1月-2015年8月浙江省永康市中医院收治的197例NHL患者和随机抽取同期住院的500例其他肿瘤患者(原发性肝癌除外)和150例门诊健康体检者乙肝二对半的检测结果。结果 NHL组、肿瘤对照组和健康对照组HBs Ag阳性率分别为21.3%、12.2%和8.7%,NHL组HBs Ag阳性率明显高于肿瘤对照组和健康对照组,差异有统计学意义(P<0.01)。在NHL两亚型之间,B细胞型NHL HBs Ag阳性率(25.7%)明显高于T细胞型NHL HBs Ag阳性率(10.4%),差异有统计学意义(P<0.01)。T细胞型NHL HBs Ag阳性率与肿瘤对照组及健康对照组差异无统计学意义(P>0.05)。结论NHL患者HBV感染率明显高于其他肿瘤患者,B细胞型NHL患者的感染率高于T细胞型NHL患者,提示HBV持续感染可能在NHL尤其在B细胞型NHL发病中起重要作用。Objective To investigate the infection rate of hepatitis B virus（ HBV） in patients with non- Hodgkin lymphoma（ NHL）. Methods A total of 197 patients with NHL,500 patients with other cancers（ except the primary liver carcinoma） and150 cases of normal people from January 2009 to August 2015 in Yongkang Traditional Chinese Medicine Hospital were collected for Chi- square test. And the results were retrospectively analyzed. Results The positive rates of HBs Ag among the NHL group,tumor control group and the healthy control group were 21. 3%,12. 2% and 8. 7%,respectively,and the positive rate of HBs Ag in NHL group was significantly higher than other cancers group or health control group,and the differences were statistically significant（ P 〈0. 01）. HBs Ag- positive rate（ 25. 7%） of B- cell NHL subgroup was significantly higher than that of the T- cell NHL subgroup（ 10. 4%）,with the difference statistically significant（ P 〈0. 01）. The difference of HBs Ag- positive rate between T- cell NHL subgroup and the other cancers group,the health control group was not statistically significant（ P 〈0. 05）. Conclusion The HBV infection rate in NHL patients was higher than that in other cancer patients,especially with that in patients with B- cell NHL higher than that in patients with T- cell NHL,suggesting a possible role of continual HBV infection in the occurance of non- Hodgkin＇s lymphoma,especially the B- cell NHL.

关 键 词：淋巴瘤 非霍奇金 乙型肝炎病毒 感染 

分 类 号：R733.1[医药卫生—肿瘤]