102例老年结肠癌患者预后因素分析  

Prognostic Factors in 102 Elderly Cases with Colon Cancer

作　　者：张宝昕 赵军[2] 潘宏达[2] 高兆亚 陈鹏举[2] 顾晋[2] 

机构地区：[1]沧州中西医结合医院,河北沧州061001 [2]北京大学肿瘤医院,北京肿瘤医院暨北京市肿瘤防治研究所,恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《肿瘤学杂志》2016年第5期365-368,共4页Journal of Chinese Oncology

摘　　要：[目的]探讨影响老年结肠癌患者预后的因素。[方法]回顾分析102例老年结肠癌患者临床病理资料,对可能影响患者生存的因素进行单因素和Cox多因素回归分析。[结果]全部患者3年总生存率为80.4%。单因素分析发现术前血清CEA水平>5ng/ml、血清CA199水平>37U/ml、肿瘤分化程度低、更高的T分期、N分期、M分期是影响患者预后的因素(P<0.05)。多因素回归分析显示肿瘤分化程度(P=0.013)、T分期(P=0.011)、M分期(P=0.000)是影响患者预后的独立危险因素。[结论]根据肿瘤分化程度、T分期、远处转移可以对具有预后不良因素的老年结肠癌患者进行更准确的风险分层,针对此类高危患者临床上应采取更积极的治疗以及术后更加密切的随访。[Objective] To investigate the prognostic factors of elderly colon cancer.[Methods]Clincicopathologic data of 102 elderly cases with colon cancer were analyzed retrospectively.Un-variate and multivariate analyses were conducted to identify prognostic factors in elderly colon cancer.[Results] The 3-year overall survival（OS） was 80.4%.Univariate analysis showed that preoperative CEA level 〉5ng/ml,CA199 level 〉37U/ml,poor differentiation,higher T stage,higher N stage,higher M stage were the poor prognostic factors of patients with colon cancer（P〈0.05）.Multivariate analysis found that higher T stage（P=0.011）,poor differentiation（P=0.013）,higher M stage（P=0.000）were the independent prognostic factors in elderly colon cancer.[Conclusion] According to the prognostic risk factors of differentiation,T stage and distant metastasis,more accurate risk stratification might be conducted in elderly patients with colon cancer,who should be considered as candidates for receiving more intensive treatment and surveillance.

关 键 词：老年人 结肠肿瘤 预后 多因素分析 

分 类 号：R735.35[医药卫生—肿瘤]