EBV病毒阳性T／NK细胞淋巴增生性疾病1例  

A Case of Epstein-Barr Virus-positive T / NK-cell Lymphoproliferative Disorder

作　　者：徐鹏杰 丁媛[2] 赵肖庆[3] 施若非[3] 罗全生 郑捷[3] 

机构地区：[1]山西省运城市皮肤病医院(山西省运城市第四人民医院皮肤科),山西运城044000 [2]新疆维吾尔自治区人民医院皮肤性病科,新疆乌鲁木齐830001 [3]上海交通大学医学院附属瑞金医院皮肤科,瑞金-耶鲁皮肤淋巴瘤治疗中心,上海200092

出　　处：《中国皮肤性病学杂志》2016年第6期604-606,共3页The Chinese Journal of Dermatovenereology

摘　　要：患者女,19岁。右面部肿胀1年,加重1周。皮损组织病理示:真皮血管,附属器周围及皮下脂肪小叶内片状淋巴细胞浸润,细胞小到中等,部分细胞核有异型,组化T标记阳性CD2,CD3,UCHL-1,CD4,CD5,CD7,CD8阳性;CD56阴性,原位杂交中还发现了少量的EBER;血清中EBNA Ig G:600↑,VCA Ig G:750↑;外周血、骨髓流式中发现CD16,CD56高表达。诊断:EBV病毒阳性T/NK细胞淋巴增生性疾病。A 19-year-old female presented with right facial swelling for 1 year and aggravated for 1 week. Histopatho- logic examination showed diffuse infiltrate of lymphoid ceils with an angiocentric and periappendageal pattern in the dermis and subcutis. Some of the small to middle sized lymphoid ceils had significant heternmor- phism, Immnnohistochemical stains showed positive for CD2, CD3, UCHL-1, CD4, CD5, CD7, CD8, but neg- ative for CD56. Epstein-Barr virus-encoded RNA （EBER） was positive. The viral serological diagnosis showed EBV IgG positivity（ EBNA IgG： 600↑ , VCA IgG： 750↑）. The peripheral blood and bone marrow flow cytometry showed a significantly higher level of CD16 and CD56. The diagnosis was made as Epstein- barr virus-positive T/NK-cell lymphoproliferative disorder.

关 键 词：T/NK细胞淋巴增生 EB病毒 

分 类 号：R739.5[医药卫生—肿瘤]