维持皮肤屏障研究进展--脂质的分泌及组成  

Advancement in Maintaining Skin Barrier—Secretion and Composition of Lipid

作　　者：崔乐[1] 贾焱[1] 成志伟[1] 高莹[2] 张高磊[2] 李靖怡[3] 何聪芬[1] 

机构地区：[1]北京工商大学理学院北京市植物资源研究开发重点实验室,北京100048 [2]首都儿科研究所皮肤科,北京100020 [3]中国人民大学附属中学高中部,北京100080

出　　处：《中国皮肤性病学杂志》2016年第6期640-643,共4页The Chinese Journal of Dermatovenereology

基　　金：北京市教委科研计划项目(SQKM201610011008);中国化妆品协同创新研究中心项目(19008001060);北京工商大学研究生科研能力提升计划资助项目

摘　　要：皮肤屏障不仅能够阻挡外界有害物质对人体的伤害,还能防止体内营养物质和水分的流失。本文综述了与皮肤屏障相关的脂质分泌过程及其主要成分,如神经酰胺(ceramides,CERs)、游离脂肪酸(free fatty acid,FFAs),胆固醇(cholesterol,CHOL)等的含量、结构或比例的变化对皮肤屏障的影响研究进展。以期为开发针对维持和修复皮肤屏障功能的护肤产品和洗涤用品等提供理论依据。Human skin barrier has an important role in protecting and defense, reflected in the not only be able to re- sist harmful substances into the human body, but also to prevent loss of body water and nutrients, etc. Once the skin barrier is damaged, there will be dry, scaling, wrinkles and a series of skin problems. In this pa- per,we reviewd the secretion of skin lipids and the lipid composition like eeramides, free fatty acids and cho- lesterol about the skin barrier function and structure. Hope to provide a theoretical basis for the development of maintenance and repair of the skin barrier function for skin care products.

关 键 词：皮肤屏障 神经酰胺 游离脂肪酸 胆固醇 

分 类 号：R751[医药卫生—皮肤病学与性病学]