腺相关病毒抗肿瘤研究进展  

Advances in adeno-associated virus antitumor therapy

作　　者：邹振玉[1] 杜晓辉[1] 李荣[1] 

机构地区：[1]解放军总医院普通外科,北京100853

出　　处：《解放军医学院学报》2016年第7期804-806,809,共4页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金面上项目(61471397)~~

摘　　要：腺相关病毒(adeno-associated virus,AAV)以其较高的感染效率、低致病性、低免疫原性、介导外源基因长期稳定表达等优势成为最有前景的肿瘤基因治疗载体,并已成功用于传递和转导各种肿瘤治疗基因,包括自杀基因、抗血管生成基因、免疫相关基因等,以抑制肿瘤发生、发展和转移。本文就AAV的生物学特点及其介导的抗肿瘤研究和应用进展进行综述。Adeno-associated virus（AAV） is becoming the most promising vector for tumor gene therapy due to its superiority to other gene-carrying vectors,such as high transferring ability,low pathogenicity,low host immune response,and long-term gene expression.AAV has been successfully used to deliver and transfer a variety of therapeutic genes to cancer cells,including suicide genes,anti-angiogenic genes,and immune-related genes,to inhibit tumor initiation,growth and metastasis.Herein,we review the biological features and advances in research and application of AAV-mediated cancer gene therapy.

关 键 词：腺相关病毒 肿瘤 基因转移技术 

分 类 号：R733.6[医药卫生—肿瘤]