丁苯酞改善Binswanger病患者脑血管反应性及认知功能的临床研究  

Clinical study on dl-3n-butylphthalide in improving cerebrovascular reactivity and cognitive function in patients with Binswanger disease

作　　者：周瑜[1] 梁静静[1] 曾艳平[1] 罗瑛[1] 黄兴汉[1] 卢祖能[1] 

机构地区：[1]武汉大学人民医院神经内科,武汉430060

出　　处：《实用药物与临床》2016年第5期576-579,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨丁苯酞对Binswanger病患者脑血管反应性及认知功能的影响。方法将60例Binsw anger病患者随机分为治疗组和对照组,每组30例,对照组给予长春西汀注射液静滴,治疗组在此基础上给予丁苯酞软胶囊口服,200 mg/次,3次/d;疗程为2周。治疗前后应用经颅多普勒超声屏气试验评价脑血管反应性,同时进行P300数据采样和MMSE、HDS量表评分以及疗效评价。结果丁苯酞治疗后大脑中动脉的平均流速和血管反应性显著改善,治疗组治疗前、后P300波潜伏期及P300波幅比较,差异均有统计学意义(P<0.05);M M SE和HDS量表评分显著改善,治疗组有效率为73.3%,明显高于对照组的46.7%,差异有统计学意义(P<0.05)。结论丁苯酞治疗Binsw anger病安全有效。Objective To investigate the effects of dl-3n-butylphthalide on cerebrovascular reactivity and cognitive function in patients with Binswanger disease（ BD）. Methods Sixty patients with BD were randomly assigned into treatment group and control group,30 patients in each group. Both groups were given vinpocetine intravenously once a day for two weeks, and treatment group were also given dl-3n-butylphthalide orally, 200 mg once,3 times a day.Transcranial color Doppler ultrasound and breathing-holding test were used to detect the mean velocity of double side middle cerebral artery（ MCA） and cerebrovascular reactivity. The therapeutic effects were measured with Event-related potential P300,MMSE and HDS. Results The mean velocity and cerebrovascular reactivity of MCA were improved after dl-3n-butylphthalide treatment. The latency of P300 was reduced and the amplitude of P300 was increased in treatment group compared with patients before treatment, and the scores of MMSE and HDS were also improved obviously after treatment. The total effective rates of dl-3n-butylphthalide and control group were 73. 3% and 46. 7% respectively（ P〈0. 05）. Conclusion Dl-3n-butylphthalide has therapeutic potential in the treatment of Binswanger disease.

关 键 词：BINSWANGER病 脑血管反应性 认知功能 事件相关电位P300 丁苯酞 

分 类 号：R743.3[医药卫生—神经病学与精神病学]