光动力疗法治疗71例光线性角化病疗效观察  

Clinical observation of Photodynamic therapy in treatment of 71 cases with actinic keratosis

作　　者：胡瑜霞[1] 陈绍华[1] 雷东云[1] 杨绪娟[1] 农祥[1] 

机构地区：[1]昆明医科大学第一附属医院皮肤科,云南昆明650032

出　　处：《中国美容医学》2016年第5期66-68,共3页Chinese Journal of Aesthetic Medicine

摘　　要：目的：探讨5-氨基酮戊酸光动力疗法治疗光线性角化病的临床疗效与安全性。方法：选择笔者科室71例光线性角化病患者作为研究对象,给予20%5-氨基酮戊酸光动力治疗,每周治疗1次,直至皮损未进一步改善或完全消失为止,观察其疗效和复发情况。结果：在接受3~5次治疗后,有63例患者完全缓解（88.73%）,8例患者部分缓解（11.27%）,未出现无反应者;其中小皮损组和大皮损组,单发损害组和多发损害组完全缓解率均无统计学差异;对完全缓解者进行随访,4例出现复发情况,复发率为6.35%。结论：光动力疗法治疗光线性角化病疗效确切,复发率低,不良反应轻微,且其疗效差异与皮损面积和数量无关,值得在临床上推广应用。Objective To observe the efficacy and safety of 5-aminolevulinic acid photodynamic therapy（5-ALA-PDT） in the actinic keratosis（AK） treatment.Methods Seventy-one patients of AK in our department were treated once every week until the lesions without further improved or completely disappeared by the 20% 5-ALA photodynamic therapy to evaluate the clinical efficacy and recurrence.Results After 3-5 times therapies 63 patients achieved complete remission（88.73%）,8 patients achieved partial remission（11.27%）and no response was observed.While the rate of complete remission had no difference between small and large,single and multiple skin lesions group.In the course of follow-up for cases who achieved complete remission,4 patients occurred recurrence and the recurrence rate was 6.35%.Conclusion The effect of PDT in the treatment of AK with mild adverse reactions and small recurrence rate was excellent and not relevant to the size and quantity of lesions.It is worth clinical popularizing.

关 键 词：氨基酮戊酸 光动力疗法 光线性角化病 临床疗效 复发 

分 类 号：R739.5[医药卫生—肿瘤]