B7-H4介导肿瘤免疫逃逸机制及临床研究进展  

The role of B7-H4 in immune escape and its clinical research progress

作　　者：吴贞[1] 章宏[2] 

机构地区：[1]杭州市肿瘤医院肿瘤综合治疗科,杭州310002 [2]浙江大学附属第一医院消化内科,杭州310003

出　　处：《上海医药》2016年第10期11-14,共4页Shanghai Medical & Pharmaceutical Journal

基　　金：浙江省科技厅课题公益项目(2014c33205)

摘　　要：协同刺激分子B7-H4是B7家族中的新成员,能通过抑制T细胞增殖、减少细胞因子产生和减慢细胞周期进程而负性调控T细胞免疫应答。研究表明,B7-H4在多种肿瘤细胞及组织中均呈高表达,与肿瘤免疫逃逸关系密切,在肿瘤的发生、发展和转归中发挥重要作用。研究B7-H4在肿瘤中的表达和意义,有助于阐明肿瘤免疫逃逸机制,也为肿瘤的免疫治疗提供新的靶点和策略。Costimulatory molecule B7-H4,which is a new member of B7 family,can negatively regulate T cell immune response by inhibiting T cell proliferation,reducing cytokine production and slowing down cell cycle.Studies have shown that B7-H4 was highly expressed in many tumor cells and tissues.It is closely related with tumor immune escape,and plays an important role in the occurrence,development and prognosis of tumors.Study of B7-H4 expression in malignant tumors is helpful to clarify the mechanism of tumor immune escape and offers new strategy to pursue for molecule targeted treatment in cancer.

关 键 词：肿瘤 B7-H4 免疫逃逸 

分 类 号：R730.3[医药卫生—肿瘤]