rt-PA治疗急性脑梗死伴心房颤动的疗效观察  

Effect of rt-PA on Treatment of Acute Ischemic Stroke Patients Accompanied with Atrial Fibrillation

作　　者：林锦超[1] 康德[1] 王翠玉[1] 

机构地区：[1]解放军第175医院(厦门大学附属东南医院)急诊科,福建漳州363000

出　　处：《神经损伤与功能重建》2016年第3期216-218,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨重组组织型纤溶酶原激活剂(rt-PA)治疗急性脑梗死伴房颤的疗效。方法:选取急性脑梗死伴房颤患者40例为观察组,另选取同期收治的急性脑梗死无房颤患者40例为对照组。2组均在发病4.5 h内使用rt-PA进行静脉溶栓治疗,观察治疗后继发性脑出血的发生率和死亡率,以及治疗后24 h、2周、1月的NIHSS评分和治疗1、3月后的m RS评分。结果:2组治疗后继发性脑出血的发生率和死亡率差异无统计学意义(均P>0.05)。观察组治疗后24 h、2周、1月时NIHSS评分和治疗1月后的m RS评分高于对照组,差异有统计学意义(均P<0.05)。结论:rt-PA能有效治疗发病4.5 h内的伴有房颤的急性脑梗死患者。Objective：To explore the clinical effect of rt-PA on the the treatment of patients with acute ischemic stroke（AIS） and atrial fibrillation（AF）. Methods： Forty AIS patients with AF were enrolled as the observation group, and another 40 AIS patients with non-AF during the same period were enrolled as the control group. All patients were treated with rt-PA intravenous thrombolytic therapy within 4.5 h after onset. The occurrence rate of secondary cerebral hemorrhage and mortality rate after thrombolysis, the NIHSS scores on 24 h, 2 weeks and 1month and the m RS scores on 1 and 3 month after thrombolysis were compared. Results： There was no significant difference in the occurrence rate of secondary cerebral hemorrhage and mortality rate after thrombolysis between the two groups（P〉0.05）. The NIHSS scores on 24 h, 2 weeks and 1 month after thrombolysis and the m RS score on 1 month after thrombolysis of the observation group were higher than those of the control group（all P〈0.05）. Conclusion： rt-PA can effectively treat the AIS patients with AF within 4.5 h of the onset with safety.

关 键 词：重组组织型纤溶酶原激活剂 急性脑梗死 心房颤动 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学]