绿色反应介质乳酸乙酯在有机合成中的应用研究进展  

Recent Advances in Organic Synthesis Employing Ethyl Lactate as Green Reaction Medium

作　　者：韦丽[1] 陈绪文[1] 刘云云[1] 万结平[1] 

机构地区：[1]江西师范大学化学化工学院,南昌330022

出　　处：《有机化学》2016年第5期954-961,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21562025);江西省自然科学基金(No.20151BAB203008)资助项目~~

摘　　要：生物质来源的乳酸乙酯作为一种新型的绿色有机反应介质逐渐受到人们的关注.这一溶剂具有无毒、生物可降解、廉价易得、沸点高、同时对水和多数有机物的优秀互溶性等各种符合理想绿色介质的优点.近几年来,以乳酸乙酯为溶剂成功实现了包括Suzuki偶联反应、Glaser偶联反应以及各类具有生物活性杂环化合物的串联合成等反应.本文结合我们自己的研究工作和兴趣,系统综述了近年来以乳酸乙酯为反应介质的有机合成反应研究进展.The biomass-derivable ethyl lactate has been attracting daily increasing attention as a green medium in organic synthesis. The unique advantages of nontoxicity, low cost, complete biodegradability, high boiling point, and excellent compatibility to water and most organic compounds of this solvent cater well to the property of a green reaction medium. In recent years, ethyl lactate（EL） has been successfully used as medium in different types of organic reactions, including Suzuki-Miyaura reaction, Glaser reaction as well as cascade synthesis of heterocyclic compounds with biological activities. Based on our own research interest in this issue, the advances in organic synthesis employing EL as a green medium are summarized.

关 键 词：绿色介质 乳酸乙酯 偶联反应 缩合反应 串联反应 

分 类 号：O621.25[理学—有机化学]