母体不同妊娠年龄及孕期25-羟维生素D水平及甲状腺功能分析  

Analysis of 25-hydroxy vitamin D level and thyroid function in pregnant women of different gestational stages and different gestational ages

作　　者：廖长征[1] 徐文莉[1] 李康[1] 罗艺[1] 张洪德[1] 林燕华[1] 

机构地区：[1]深圳市龙岗中心医院中心实验室,广东深圳518116

出　　处：《现代医学》2016年第5期653-656,共4页Modern Medical Journal

摘　　要：目的：探讨各期妊娠期及各年龄段母体25-（OH）D及甲状腺激素的水平,并了解二者间的相关性。方法：选取2014年8月至2015年7月既往无甲状腺相关疾病史的妊娠孕妇1 029名。所有孕妇按孕周分为孕早期组（0～12＋6周）、孕中期组（13～27＋6周）、孕晚期组（28周～分娩）;按年龄分为A组（〈25岁）、B组（≥25岁而≤30岁）、C组（〉30岁）。运用串联质谱仪检测维生素D水平,甲状腺相关激素由全自动电化学发光免疫分析仪完成测定。结果：25-（OH）D和甲状腺激素水平在各年龄组间差异无统计学意义（P〉0.05）,而25-（OH）D水平随着年龄升高呈升高的趋势。25-（OH）D水平随着孕期增加而升高,差异有统计学意义（P〈0.05）,孕妇在不同妊娠期血清25-（OH）D营养缺乏情况普遍存在,组间比较差异有统计学意义（P〈0.05）;FT3、FT4随着孕期增加而降低,而TSH水平孕中期及孕晚期明显升高,差异均有统计学意义（P〈0.05）。25-（OH）D与甲状腺激素间无相关性（P〉0.05）。结论：孕妇妊娠阶段与25-（OH）D及甲状腺激素水平密切相关,甲状腺激素水平与25-（OH）D无相关,孕妇普遍存在25-（OH）D不足或缺乏。Objective： To discuss the levels of 25-hydroxy vitamin D[25-（ OH） D]and thyroid hormones at different gestational stages and different gestational ages,and assess the relationship between them. Methods：1 029 pregnant women without thyroid related medical history from August 2014 to July 2015 were selected for the study. All these gravidas were divided into first trimester group（ 0-12^＋ 6weeks）,second trimester group（ 13-27^＋ 6weeks） and third trimester group（ 28 weeks-delivery） by the duration of pregnant. 1 029 pregnant women were divided into group A（ 〈25 years old）,group B（ ≥25 and ≤30 years old）,group C（〉 30 years old） according to the age. The detection of 25-hydroxy vitamin D were performed using tandem mass spectrometer. Thyroid hormones were measured by electrochemical immunoassay. Results： The difference of 25-（ OH） D and thyroid hormones were not found among the three age group（ P〈0. 05）,but 25-（ OH） D increased with age. 25-（ OH） D and TSH differently increased with pregnancy cycle（ P〈0. 05）,25-（ OH） D nutrition deficiency was common in pregnant women at different gestational stages,and there were significant differences among the three groups（ P〈0. 05）.FT3 and FT4 differently decreased（ P〈0. 05）. 25-（ OH） D level was not correlated with thyroid hormones（ P〈0. 05）. Conclusion： 25-（ OH） D and thyroid hormones levels are closely related to the gestational stages,and there is not correlative between thyroid hormones and 25-（ OH） D. Pregnant women widely have deficiency of 25-（ OH） D.

关 键 词：25-羟维生素D 孕妇 甲状腺激素 

分 类 号：R714.14[医药卫生—妇产科学]