微小RNA-92a在相关疾病发病机制中的研究进展  

The Advancement of MiR-92a in the Pathogenesis of Related Diseases

作　　者：邹仁超 王剑松[1] 王海峰 

机构地区：[1]昆明医科大学第二附属医院泌尿外科,云南昆明651000

出　　处：《医学与哲学（B）》2016年第4期58-60,70,共4页Medicine & Philosophy(B)

基　　金：2014年度云南省教育厅科学研究基金;项目编号:2014Z072;2014年度云南省卫生科技计划项目;项目编号:2014NS081;2014年度云南省卫生科技计划项目;项目编号:2014FZ031

摘　　要：miRNA-92a家族基因是由miRNA-25、miRNA-92a^1和miRNA-92a^2等序列相似、结构相仿、种子区序列相同的微小RNA组成,它们分别来自在进化过程中高度保守并互为旁系同源序列的miRNA-106b^25、miRNA-17~92和miRNA-106a^363基因簇。目前研究认为,miRNA-92a家族基因是一组与血管内皮细胞形成有关的miRNAs,其表达紊乱与肿瘤的发生发展密切相关。本文就miRNA-92a家族基因在相关疾病发病机制中的研究进展进行综述。miR-92a is made of the same microRNAs （miRNAs） which are similar structure and seed sequences and made by a sequence of miRNA-25, miRNA-92a～l, miRNA-92a～2 and miRNA-363 etc. They are from the evolutionary process of the highly conserved and mutual paralogous sequence miRNA-106b～25 and miRNA-17～92 and miRNA-106a～ 363 gene cluster. PreSent research shows that miRNA-92a gene is a group of miRNAs related to the formation of vascular endothelial cells, the disorder of expression is closely related to the development of tumor. The study of a variety of human diseases involves miRNA-92a. In this review,the progress of the relationship between miR-92a family and the pathogenesis of related diseases are summarized.

关 键 词：MIRNA miR-92a 基因表达与调控 细胞功能紊乱 肿瘤 

分 类 号：R737.14[医药卫生—肿瘤]