非编码RNA与肝脏疾病  

Non-coding RNAs and liver diseases

作　　者：石娟娟[1] 党双锁[1] 

机构地区：[1]西安交通大学医学院第二附属医院感染科,陕西省西安市710004

出　　处：《世界华人消化杂志》2016年第13期1952-1959,共8页World Chinese Journal of Digestology

摘　　要：非编码RNA(non-coding RNA,ncRNA)是一类不具有编码蛋白质功能的RNA,在复制、转录和转录后等多种水平调控基因表达,参与细胞分化、个体发育和疾病发生发展等多种生物学进程.ncRNA表达或功能异常均与肝脏疾病的发生发展密切相关,目前研究显示肝细胞癌、病毒性肝炎和酒精肝损伤等肝脏疾病中有多种ncRNAs表达水平发生了显著变化,并在疾病的发生发展和预后中起着核心调控作用.因此,ncRNA的研究是生物学研究领域的热点和难点,有望成为肝脏疾病潜在的诊断标准、预后标志和临床治疗靶点.Non-coding RNAs（ncRNAs） do not code for proteins,and they regulate gene expression at replication,transcriptional,post-transcriptional and other levels and may be involved in various biological processes such as cell differentiation,individual development and pathological processes.Recent studies have suggested that aberrant expression of ncRNAs is closely related with liver diseases such as hepatocellular carcinoma,viral hepatitis,alcohol-induced liver injury,and ncRNAs play a central regulatory role in the development and prognosis of these diseases.Therefore,ncRNAs have the potential to become diagnostic and prognostic markers and clinical targets in liver diseases.

关 键 词：非编码RNA 微小RNA 长链非编码RNA 肝细胞癌 病毒性肝炎 

分 类 号：R575[医药卫生—消化系统]