Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors  

作　　者：Fei Yu Qi wang Han Wang Long-Long Si Jia-Xin Liu XU Han Su-Long Xiao Li-He Zhang De-Min Zhou 

机构地区：[1]Medical Faculty of Kunming University of Science and Technology, Kunming 650500, China [2]State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

出　　处：《Chinese Chemical Letters》2016年第5期711-713,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos. 81373271 and 81361168002);OpenFund Program of the State Key Laboratory of Natural and Biomimetic Drugs (No. K20150214);Yunnan Basic Research Project (No. 14051789)

摘　　要：A series of echinocystic acid （EA） 28-COOH derivatives was synthesized, and their anti-HCV entry activity was evaluated by HCVpp and VSVpp entry assay. It was found that some of them showed moderate anti-HCV entry activity, especially compound 12, and these modifications also removed the undesired hemolytic effect.A series of echinocystic acid （EA） 28-COOH derivatives was synthesized, and their anti-HCV entry activity was evaluated by HCVpp and VSVpp entry assay. It was found that some of them showed moderate anti-HCV entry activity, especially compound 12, and these modifications also removed the undesired hemolytic effect.

关 键 词：Triterpene Echinocystic acid HCV entry inhibitors Hemolysis 

分 类 号：R914.5[医药卫生—药物化学] R96[医药卫生—药学]