研究托吡酯对癫痫患者糖代谢的影响  

Study the Affect on Topiramate in Patients With Epilepsy in Glucose Metabolism

作　　者：姜炎[1] 牛延良[1] 王利军[1] 

机构地区：[1]郑州大学第五附属医院神经内二科,河南郑州450000

出　　处：《中国继续医学教育》2016年第13期148-149,共2页China Continuing Medical Education

摘　　要：目的探究采用托吡酯对癫痫患者糖代谢的影响。方法选取在我院住院治疗的癫痫患者120例作为研究对象,采用随机数字表法将患者分为对照组和观察组,每组60例,对照组采用丙戊酸钠治疗,观察组采用托吡酯治疗,治疗后对比两组患者血糖、IR、血胰岛素水平及不良反应发生情况。结果观察组与对照组治疗后相比较,观察组血糖、IR、血胰岛素水平改善更为明显,差异有统计学意义(P<0.05);观察组不良反应发生率24.00%,低于对照组的50.00%,差异有统计学意义(P<0.05)。结论对癫痫的患者采用托吡酯治疗的效果会更好,可减轻对神经元的损伤,保护神经,对癫痫的发作有较好的治疗效果,其药代动力学良好,药物能够更快的吸收,提高药物的利用度,利于患者糖代谢指标向正常化发展,降低治疗给患者带来的痛苦。Objective To explore the impact of the use of topiramate in patients with epilepsy sugar metabolism.Methods 120 patients with epilepsy were selected in our hospital, with random number table based on all patients were divided into control group and observation group, 60 cases in each group, the control group were treated with sodium valproate treatment, observation treatment group were treated with topiramate, compared to glucose, IR, blood insulin levels and adverse events two groups of patients after treatment situation.Results The observation group and the control group after treatment, the blood glucose, IR, blood insulin levels in observation group improved more signiifcantly, the difference were statistically signiifcant （P〈0.05）, The incidence of adverse reactions in the observation group 24.00%, was lower than the control group 50.00%, the difference was statistically signiifcant （P 〈0.05）.Conclusion Patients with epilepsy using topiramate treatment effect will be better, reduce neuronal injury, neuroprotection, epileptic seizures have a better therapeutic effect, pharmacokinetics good, faster absorption of drugs improve the utilization of the drug, which will help patients to normalize glucose metabolism indicators development, reduce pain therapy to patients.

关 键 词：癫痫 糖代谢 托吡酯 胰岛素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]