银杏叶治疗高脂血症的网络药理学研究  

Network pharmacological research of Ginkgo Folium against hypercholesterolemia

作　　者：何星垚 刘珺[2] 罗春 王晖[1] 

机构地区：[1]广东药学院,广东广州510006 [2]广西中医药大学第一附属医院,广西南宁530023 [3]广州白云山化学制药厂,广东广州510515

出　　处：《中国医院药学杂志》2016年第10期787-791,共5页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金项目(编号:81072591);广东省科技计划项目(编号:2012B060300030)

摘　　要：目的:通过网络药理学方法探究银杏叶治疗高血脂的潜在作用机制。方法:收集高脂血症的治疗靶点,银杏叶成分及其口服生物利用度,通过预测类药性,运用Mobyle的离线Autodock Vina功能进行分子对接,筛选出银杏叶治疗高脂血症的活性成分,以银杏叶活性成分及其靶点蛋白为网络节点构建网络模型,根据模型预测银杏叶治疗高脂血症潜在的药理作用机制。结果:数据库收集所得的银杏叶成分中,53.9%的成分具有较好的口服吸收利用度,61.8%的银杏叶成分可能具有较好类药性特征。银杏叶可能通过作用HMG-CoA还原酶、NPC1L、HMG-CoA合成、焦磷酸合成酶和胆汁酸受体,从而抑制胆固醇的合成与吸收。结论:银杏叶具有良好的口服吸收利用度,其作用机制可能是通过活性成分可能通过抑制胆固醇的合成与吸收达到降血脂的作用。OBJECTIVE To explore potential mechanism of Ginkgo Folium against hypercholesterolemia by network pharmaceutical method.METHODS Therapeutic targets of hypercholesterolemia,compounds of Ginkgo Folium and oral bioavailability were collected.Drug-like properties of compounds of Ginkgo Folium were predicted.Autodock Vina provided by Mobyle was used to screen active compounds.Compounds and targets were used as nodes to construct a ＂drug-target＂ interaction network and predict potential mechanism.RESULTS Of compounds of Ginkgo Folium,53.9% had good oral bioavailability and 61.8% had good drug-like properties.Ginkgo Folium might inhibit synthesis and absorption of cholesterols by targeting at HMG-CoA reductase,NPC1 L,HMG-CoA and farnesyl pyrophosphate syntheses,and bile acid receptor.CONCLUSIONCompounds of Ginkgo Folium have good oral bioavailability and drug-like properties,and may lower blood lipids by inhibiting synthesis and absorption of cholesterols.

关 键 词：分子对接 银杏叶 网络药理学 作用机制预测 

分 类 号：R966[医药卫生—药理学]