自噬与甲状腺癌的研究进展  

Autophagy and its research progress in thyroid cancer

作　　者：张思林[1] 罗庆[1] 余杰情[1] 周文胜[1] 

机构地区：[1]南昌大学第一附属医院耳鼻咽喉头颈外科,南昌330006

出　　处：《临床耳鼻咽喉头颈外科杂志》2016年第11期922-924,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：甲状腺癌是头颈外科常见的恶性肿瘤,女性较为常见,在女性高发肿瘤中排名第5位〔1〕,近年来甲状腺癌成为增长速度最快的肿瘤之一〔2〕,而且甲状腺癌的复发率高,导致治愈率明显下降,死亡率增加,给人类健康带来严重危害〔3〕。To summarize the autophagy and its research progress in thyroid cancer.In combination with available literatures published in recent years involving the relationship between autophagy and thyroid cancer,the characteristics of autophagy,the role in thyroid cancer were reviewed.The changes of autophagy level will directly or indirectly participate in the pathogenesis and progression of thyroid cancer.Reagents regulating autophagy will have broad prospect of application in thyroid cancer therapy.The autophagy in the thyroid cancer is still poorly understood,and to clarify the molecular mechanism of autophagy and kill thyroid cancer cells by reasonable regulation of autophagy still needs more further studies.

关 键 词：甲状腺肿瘤 自噬 治疗 

分 类 号：R736.1[医药卫生—肿瘤]