血清转化生长因子β1、血管内皮生长因子在布-加综合征患者中的表达研究  

Analysis of the expression of transforming growth factor-β1and vascular endothelial growth factor in Budd-Chiari syndrome

作　　者：丁晓帆[1] 张端强[1] 陆召军[1] 石月[1] 祖茂衡[2] 徐浩[2] 高修银[1] 

机构地区：[1]徐州医学院公共卫生学院,徐州221004 [2]徐州医学院附属医院介入放射科,徐州221002

出　　处：《安徽医科大学学报》2016年第6期877-880,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金资助项目(编号:81172604)

摘　　要：目的研究血清转化生长因子β1(TGF-β1)、血管内皮生长因子(VEGF)在布-加综合征(BCS)患者中的表达,探讨其在BCS病情进展中的作用。方法选取101例BCS患者作为实验组,选取健康体检者125例作为对照组。采用ELISA法检测两组人群血清TGF-β1、VEGF表达水平。结果实验组血清TGF-β1、VEGF的含量高于对照组血清TGF-β1、VEGF的含量,差异均有统计学意义(P<0.001)。实验组中单纯BCS患者、BCS合并淤血性肝硬化患者、BCS合并肝癌患者血清TGF-β1、VEGF表达水平比较,差异均有统计学意义(P<0.001),其中,BCS合并肝癌患者血清TGF-β1、VEGF水平高于BCS合并淤血性肝硬化患者,BCS合并淤血性肝硬化患者血清TGF-β1、VEGF水平高于单纯BCS患者,差异均有统计学意义(P<0.05)。BCS患者血清TGF-β1与VEGF呈正相关性(r=0.30,P=0.01)。结论随着BCS患者病情的进展,患者血清TGF-β1、VEGF表达水平增高,两因子的协同作用可能会加快病情的发展进程。Objective To study the expression of transforming growth factor-β1（ TGF-β1） and vascular endothelial growth factor（ VEGF） in Budd-Chiari syndrome,and to explore whether serum TGF-β1 and VEGF play important roles in the progression of Budd-Chiari syndrome. Methods There were 101 cases of Budd-Chiari syndrome in the experimental group. During the same period,125 controls were recruited from the medical examination center. The serum concentrations of TGF-β1 and VEGF were detected by ELISA. Results The serum concentrations of TGF-β1and VEGF in the experimental group were higher than those in the control group（ P〈 0. 001）. In the BCS group,the serum concentrations of TGF-β1 and VEGF were different significantly between pure BCS patients,BCS with stasis cirrhosis patients and BCS with hepatic carcinoma patients（ P〈 0. 001）. Among them,the serum concentrations of the two factors of BCS with hepatic carcinoma patients were higher than BCS with stasis cirrhosis patients,and the latter was higher than the pure BCS patients（ P〈 0. 05）. The serum TGF-β1 and VEGF were positive correlated in the BCS group（ r = 0. 30,P = 0. 01）. Conclusion The serum concentrations of TGF-β1 and VEGF increase with the progression of BCS,and the synergistic effect between TGF-β1 and VEGF may accelerate the development of BCS.

关 键 词：布-加综合征 转化生长因子Β1 血管内皮生长因子 肝纤维化 

分 类 号：R575[医药卫生—消化系统]