不同药物对兔耳缘静脉炎症及血栓形成的影响  

Investigation on inflammation reaction and vein thrombosis on rabbit ear vein with different drugs

作　　者：戴晴[1] 李伦兰[1] 陈学岚 

机构地区：[1]安徽医科大学第一附属医院护理部,合肥230022 [2]安徽医科大学第一附属医院动物科,合肥230022

出　　处：《安徽医科大学学报》2016年第6期910-912,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省科技厅年度攻关项目(编号:1301043045)

摘　　要：观察甲氨蝶呤、头孢曲松钠和生理盐水3种不同药物对兔耳缘静脉炎症反应及血栓形成的影响。随着药物使用时间的增加,3组静脉炎症反应和血栓形成数量均逐渐增加,化疗药组和抗生素组明显多于生理盐水组。3组在药物使用第3、7天时静脉炎症反应差异有统计学意义(P<0.05),在药物使用第7天血栓形成差异有统计学意义(P<0.05)。药物的理化性质及使用时间对静脉炎症反应及血栓的形成的影响有所差异。To observe local inflammation reaction and vein thrombosis on rabbit ear vein with methotrexate,ceftriaxone sodium and normal saline. With the extension use of drugs,the numbers of inflammation reaction and thrombosis in each group were increased,and antibiotic and chemotherapy drug group had a higher rate than the normal saline group. There was a statistically significant difference of the inflammation reaction between the three test groups on the 3rd and 7th day（ P 〈0. 05）,and a statistically significant difference of thrombosis between the three test groups on the 7th day（ P〈 0. 05）. The physical-chemical properties of drugs and use of time were factors influencing inflammation reaction and thrombosis.

关 键 词：炎症 静脉血栓形成 药用制剂 

分 类 号：R364.5[医药卫生—病理学] R364.15[医药卫生—基础医学]