首发为Fisher综合征表现的肺癌转移致脑膜癌病一例  

Meningeal carcinomatosis starting for Fisher syndrome performance

作　　者：张洁[1] 关鸿志[2] 邢岩[1] 李剑[1] 吴玉冰[1] 杨琼[1] 

机构地区：[1]航空总医院神经内科,北京100023 [2]北京协和医院神经内科

出　　处：《脑与神经疾病杂志》2016年第6期372-376,共5页Journal of Brain and Nervous Diseases

摘　　要：目的报告1例首发表现为Fisher综合征的脑膜癌病(MC),探讨其临床表现、影像及脑脊液(CSF)改变的特点。方法对1例首发症状表现Fisher综合征的MC进行病史采集和临床查体,分析其影像和CSF结果。结果患者以典型的Fisher综合征起病,后逐渐出现纳差、呕吐等颅高压表现,头颅MRI表现为脑干脑膜广泛强化,PET-CT提示肺癌并脑膜及骨转移。CSF发现肿瘤细胞。结论首发症状为Fisher综合征的肺癌转移致MC临床罕见,临床症状的多样性是MC容易误诊的主要原因。Objective To report a case with initial presentations for Fisher syndrome of meningeal carcinomatosis, and to investigate its clinical manifestations, imaging changes and cerebrospinal fluid （CSF）. Methods A detailed history and clinical examination were taken for a patient with initial presentations for Fisher syndrome diagnosed meningeal carcinomatosis, analyzed his imaging and cerebrospinal fluid examination results. Rseults The clinical manifestations of patients with typical Fisher syndrome, after gradually appearing vomiting and other intracranial hypertension MRI showed extensive brainstem and meningeal enhancement. PET-CT prompt, lung cancer and bone and meningeal metastases. Cancer ceils were found in csf. Conclusion The first symptoms of fisher syndrome of meningeal carcinomatosis clinical by lung cancer metastasis is rare, a diversity of c]inical symptoms is the main reason of meningeal carcinomatosis is easily misdiagnosed.

关 键 词：脑膜癌病 FISHER综合征 肺癌 

分 类 号：R739.4[医药卫生—肿瘤]