miR-30 c-5p在肿瘤中表达和功能的研究进展  

Research progress in expression and functions of miR-30 c-5p in human cancers

作　　者：杨晓冬[1] 陈力[1] 金玉麟 王琳[1] 詹成[1] 时雨[1] 王群[1] 

机构地区：[1]复旦大学附属中山医院胸外科,上海200032

出　　处：《复旦学报（医学版）》2016年第3期362-367,共6页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金(81401875;81472225);上海市自然科学基金(14ZR1406000)~~

摘　　要：miR-30 c-5p是miR-30家族的重要成员,研究表明其在肺癌、乳腺癌、前列腺癌、子宫内膜癌等多种肿瘤组织以及患者血浆、血清中表达异常,并且其作用于肿瘤的增殖、侵袭和迁移以及多种肿瘤相关基因和通路等,暗示其在肿瘤诊断、治疗、监测和预后预测等方面有一定的应用价值。本文就miR-30 c-5p在肿瘤中表达和功能的研究进展进行简要综述。miR-30 c-5p is an important member of miR-30 family.Current evidence has shown that miR-30 c-5p is deregulated in tissue samples,serum and plasma of cancer patients,including lung cancer,breast cancer,prostate cancer and endometrial cancer.The aberrant expression of miR-30 c-5p is relevant to proliferation,invasion and migration of cancer,suggesting its potential value in early diagnosis,treatment and prognosis prediction.This article reviews the research progress of miR-30 c-5p expression and function in human cancers.

关 键 词：miR-30 c-5p 肿瘤 上皮间质内转化 耐药 

分 类 号：R73[医药卫生—肿瘤]