同型半胱氨酸与鼻咽癌相关性及其机制研究  

Correlation of homocysteine and nasopharyngeal carcinoma and and the study on it′s pathogenesis

作　　者：吕蓉[1] 

机构地区：[1]广东省中山市中医院,528400

出　　处：《国际检验医学杂志》2016年第11期1515-1516,1527,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨同型半胱氨酸(Hcy)和血清超敏C-反应蛋白(hs-CRP)水平的关系,明确Hcy和hs-CRP水平与鼻咽癌发生的关系,以明确Hcy是否为鼻咽癌的危险因素。方法收集2012年1月至2014年7月中山市中医院肿瘤科收治并确诊为鼻咽癌的患者72例,另选取同期体检的50例志愿者作为健康对照组,鼻咽癌患者分为鼻咽癌缓解组和鼻咽癌未缓解组。收集入选研究对象清晨空腹静脉血测定血浆Hcy和hs-CRP水平。结果与健康对照组比较,鼻咽癌缓解组、未缓解组治疗前血浆Hcy和hs-CRP水平显著升高,差异均有统计学意义(t=9.08,P=0.023;t=6.84,P=0.035);与鼻咽癌缓解组治疗前比较,鼻咽癌未缓解组治疗前血浆Hcy和hs-CRP水平显著升高,差异均有统计学意义(t=10.94,P=0.018;t=8.67,P=0.026);与鼻咽癌缓解组治疗前比较,鼻咽癌缓解组治疗后血浆Hcy和hs-CRP水平显著降低,差异有统计学意义(t=7.15,P=0.030;t=5.34,P=0.047);与鼻咽癌未缓解组治疗前比较,鼻咽癌未缓解组治疗后血浆Hcy和hs-CRP水平降低,但差异无统计学意义(t=1.05,P=0.072;t=1.84,P=0.064)。鼻咽癌患者血浆Hcy与hs-CRP水平之间有直线相关关系,呈正相关,相关系数为0.522。结论血浆Hcy和hs-CRP水平变化与鼻咽癌严重程度和治疗效果均有正相关性,为临床早期诊断和提高治疗效果提供了参考依据。Objective To explore the correlation of homocysteine（Hcy）,high sensitivity-C reactive protein（hs-CRP）and nasopharyngeal carcinoma（NPC）and to demonstrate whether Hcy is the risk factors of NPC.Methods 72 patients with NPC collected in the hospital from January 2012 to July 2014 were divided into NPC remission group and NPC non-remission group.50 healthy people were chosen as case control.Fasting venous blood were collected from all the individuals to detect serum Hcy and hs-CRP levels.Results Compared with the healthy group,Hcy and hs-CRP levels of patients in NPC remission group and NPC non-remission group before therapy were significantly higher（t=9.08,P=0.023;t=6.84,P=0.035）.Before therapy,Hcy and hs-CRP levels of patients in NPC non-remission group were significantly higher than that in NPC remission group（t=10.94,P=0.018;t=8.67,P=0.026）.Meanwhile,Hcy and hs-CRP levels of patients in NPC remission group before therapy were significantly lower than that of patients after therapy（t=7.15,P=0.030;t=5.34,P=0.047）.The differences of Hcy and hs-CRP levels of patients in NPC non-remission group before therapy and after therapy had no statistic significance（t=1.05,P=0.072;t=1.84,P=0.064）.And the level of Hcy was positively correlated with hs-CRP（r=0.522,P〈0.05）.Conclusion Hcy and hs-CRP levels are related to the development and clinical therapy effect of NPC,which could provide a basis for early diagnosis and improvement of the treatment effect.

关 键 词：鼻咽癌 血浆同型半胱氨酸 相关性 血清超敏C-反应蛋白 

分 类 号：R739.63[医药卫生—肿瘤]