阿尔茨海默病大鼠模型建立及葛根素对大鼠空间学习记忆的影响  

The construction of Alzheimer′s disease rats model and the effects of puerarin on rat spatial learning and memory

作　　者：李冬[1] 田寅[2] 宫宇[1] 王曦[1] 

机构地区：[1]佳木斯大学附属第一医院药剂科,黑龙江佳木斯154007 [2]佳木斯大学附属第一医院肿瘤外科,黑龙江佳木斯154007

出　　处：《重庆医学》2016年第16期2180-2181,2185,共3页Chongqing medicine

基　　金：佳木斯大学青年基金项目(Sq2013-021)

摘　　要：目的探讨葛根素对β-淀粉样蛋白(Aβ1-42)诱导的阿尔茨海默病(AD)大鼠空间学习记忆障碍的影响。方法采用双侧海马注射Aβ1-42诱导AD大鼠模型。造模后3d起,葛根素按不同剂量灌胃给药28d,给药结束后采用Morris水迷宫测试系统,检测大鼠空间学习记忆能力。结果模型组大鼠表现出明显的学习记忆能力障碍,而葛根素高、中、低剂量组干预则显著地改善了AD大鼠学习记忆能力。结论葛根素能部分的提高AD模型大鼠的空间学习记忆能力。Objective To research the effects of puerarin on Alzheimer＇s disease（AD） rats spatial learning and memory disorder induced by Aβ1-42. Methods Bilateral hippocampal injection of Aβ1-42 was used to induced AD model rats. All rats underwent gavage administration with puerarin with different dose for 28 d since the 3rd day after the construction of model; and the Morris water maze was used to test the spatial learning and memory ability of rats. Results The model group rats showed obvious learning and memory disorder, and the ability of learning and memory disorder of rats in the high, medium and low dose of puerarin intervention group were significantly improved. Conclusion Puerarin can improve the spatial learning and memory ability of AD model rats.

关 键 词：阿尔茨海默病 葛根素 空间学习记忆 

分 类 号：R749.16[医药卫生—神经病学与精神病学]