PET-CT及肺癌相关肿瘤标志物检查对细支气管肺泡癌早期诊断的研究  

作　　者：顾国忠[1] 王春媛[1] 候衍修 李海涛[1] 白艳玲[1] 才立萍[1] 

机构地区：[1]大庆油田总医院呼吸科,黑龙江163000

出　　处：《当代医学》2016年第18期17-18,共2页Contemporary Medicine

摘　　要：目的探讨PET-CT及肺癌相关肿瘤标志物检查对细支气管肺泡癌早期诊断的研究。方法回顾性分析住院确诊病例41例,就其年龄、性别、临床表现、胸部影像学特征、吸烟情况、PET-CT及肺癌相关肿瘤标志物检查行临床分析。结果男13例,平均年龄(58.00±11.10)岁,女28例,平均年龄(62.44±8.76)岁;临床首发症状:咳嗽15例,咯痰10例,胸痛7例,咯血4例,胸闷3例,发热及乏力各1例;胸部影像学特征:高密度单发结节影28例,单发磨玻璃样结节影10例,结节边缘见毛刺影1例,结节边界呈分叶状影1例,胸膜凹陷征1例;PET-CT(正电子-电子计算机断层扫描)检查22例,SUV(standard uptake value,标准摄取值)值增高14例,SUV值正常8例,均未见远处脏器转移;肿瘤标志物检测:癌胚抗原(CEA)检查30例,仅6例升高。结论细支气管肺泡癌以老年女性多见,临床症状咳嗽多见,缺乏特异性,1/2患者以体检发现肺小结节影就诊,胸部影像学以肺孤立小结节影多见,单发磨玻璃影也较多见,PET-CT检查发现SUV值增高或延迟现象增高对此病诊断有较高特异性,本病生长缓慢、恶性度低,远处转移少见,手术切除机会多。Objective To explore the research of PET/CT tomography and tumor markers for the diagnosis of early stage bronchioloalveolar carcinoma.Methods Various clinical parameters were analyzed in 41 patients with early stage bronchioloalveolar carcinoma. The main work included ages, gender, clinical manifestations, chest imaging characteristics, smoking status, PET-CT and lung cancer tumor markers.Results 13 cases of male, the average age was （58.00±11.10） years old, 28 cases of female, the average age was （62.44±8.76） years old. The initial clinical symptoms： 17 cases cough, 10 cases of cough up phlegm, 19 cases of chest nodules shade which were found in medical examination, 7 cases of chest pain, hemoptysis in 4 cases, fever and fatigue in 1 case. The features of chest radiographic： high density single nodule 28 cases, Lobulated single-shot grinding glass sample nodular shadows in 10 cases, speculate boundary shadows in 1 case, nodosity with lobular in 1 case and pleural indentation 1 case. PET–CT had been carried out on the 22 cases, SUV increased in 14 cases value, the delays in 15 cases, 7 cases of normal SUV value. There was no cancer spread to distant organs metastasis. Tumor markers showed that 30 cases of carcinoembryonic antigen （CEA）, only 6 cases increased. Conclusion Most bronchioloalveolar carcinoma were found in elderly women, the clinical atypical sympotoms showed to have cough. The clinical characters are lack of speciifcity, and half patients see a doctor who found pulmonary nodules shadow in medical examination, and there are more isolated nodules shadow in chest imaging, also were found more single ground glass shadow. The increased value of SUV or delay phenomenon has higher speciifcity diagnosis on this disease. The clinical features of bronchioloalveolar carcinoma are grows slowly with low malignant degree, rare distant metastasis, and more opportunity of surgical remova.

关 键 词：细支气管肺泡癌 诊断 

分 类 号：R734.2[医药卫生—肿瘤]