炎症与子宫内膜癌的相互影响  

The Relationship between Inflammation and Endometrial Cancer

作　　者：李莉莉[1] 范江涛[1] 

机构地区：[1]广西医科大学第一附属医院妇科,南宁530021

出　　处：《国际妇产科学杂志》2016年第3期323-326,共4页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(81360388)

摘　　要：炎症与子宫内膜癌的发生、发展密切相关,过量表达的炎症因子往往与疾病密切相关。研究发现,许多恶性肿瘤患者血清中可检测到各种炎症因子的含量超过正常人,肿瘤微环境中的各种炎症介质都有利于肿瘤的增殖、迁移以及血管形成,并且通过炎症信号通路抑制肿瘤细胞的凋亡,子宫内膜癌亦是如此。炎症可通过各种炎症因子和炎症细胞促进子宫内膜癌的发生、发展,而子宫内膜癌也可表现为多种炎症特性,这都有助于子宫内膜癌的增殖和转移,抑制炎症通路可能成为治疗子宫内膜癌的一种干预措施。因此,探讨炎症与子宫内膜癌的相关性具有重要的临床意义。现就炎症与子宫内膜癌的相互影响进行综述,以期为子宫内膜癌的治疗提供新思路。Recent evidences show that inflammation plays a significant role in the development of endometrial cancer.Overexpressing of inflammatory factors is often closely related to the diseases. Studies detected that serum inflammatory factor level in cancer patients is higher than normal people. Inflammatory mediators in the tumor microenvironment are conducive to the tumor proliferation, migration and angiogenesis. And the chemokine might inhibit the apoptosis of tumor cells through the inflammatory signaling pathways. So is in endometrial cancer. Inflammation can promote the development of the endometrial cancer through a variety of inflammatory factors and inflammation cells, and endometrial cancer also shows a variety of inflammatory features, which can help the cancer cells to proliferate and metastasize. Inhibiting inflammatory pathways may become a kind of interventions for the treatment of endometrial cancer. So it is important to explore the correlation between inflammation and endometrial cancer. This paper reviewed the relationship between inflammation and endometrial cancer, providing a new method for the treatment of endometrial cancer.

关 键 词：炎症 子宫内膜肿瘤 癌 炎症趋化因子类 

分 类 号：R737.33[医药卫生—肿瘤]