补阳还五汤类方成分的药代动力学比较研究  

Comparative Study on Pharmacokinetics of Components of Buyang Huanwu Associated Prescriptions

作　　者：刘芳[1] 杨岩涛[1] 贺福元[1] 刘林[2] 吴双[1] 王宇红[2,3] 蔡光先 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湖南中医药大学第一附属医院,湖南长沙410007 [3]湖南省中药粉体与创新药物省部共建国家重点实验室培育基地中药粉体关键技术及装备国家地方联合工程实验室,湖南长沙410208

出　　处：《中国中医药信息杂志》2016年第7期82-86,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(2012CB723503);湖南省中医药科研计划项目(2014135);湖南省"十二五"中药学重点学科(2011年)

摘　　要：目的比较补阳还五汤类方(补阳还五汤和脑健片)中阿魏酸、洋川芎内酯A、藁本内酯在大鼠体内的药代动力学特征。方法将补阳还五汤类方灌胃颈静脉插管大鼠,采用HPLC-DAD法同时检测3种成分在不同时间点的血药浓度,经DAS2.0计算得单成分的药代动力学参数,再采用总量统计矩(相似度)法整合成整体药代动力学参数并进行比较。结果 3种成分在体内的总量统计参数相差甚远,而3种成分总和的统计矩参数却比较接近,补阳还五汤和脑健片在大鼠体内AUC分别为240.6和133.0,MRT分别为3.192 min和3.259 min,VRT分别为21.59 min^2和19.75 min^2;补阳还五汤和脑健片中3种成分总量的相似度达到0.977 8。结论补阳还五汤和脑健片在体内代谢过程具有相似性,中药复方发挥功效依赖于多成分的整体贡献。Objective To study the pharmacokinetic features of ferulaic acid, senkyunolide A and ligustilide in Buyang Huanwu associated prescriptions (Buyang HuanwuDecoction andNaojianTablets).MethodsHPLC-DAD was applied for simultaneous determination plasma concentration of three ingredients with jugular venous cannula rats after intragastric administration ofBuyang Huanwu associated prescriptions. The pharmacolinetic parameters of each ingredient was calculated by DAS2.0, and then the total quantum statistical moment (TQSM) standard similarity was used to measure the overall pharmacokinetics behaviors.Results There were great differences in the three ingredients after the administration of two prescriptions, while the total quantum statistical parameters were very closely. The TQSM pharmacokinetic parameters of the three components inBuyang HuanwuDecoction andNaojian Tablets showed that AUC, MRT, VRT were 240.6 and 133.0, 3.192 min and 3.259 min, 21.59 min2and 19.75 min2, respectively.The similarity was up to 0.977 8.Conclusion The metabolic processes in vivo ofBuyang Huanwu Decoction andNaojianTablets have similarities. The efficacy of Chinese herbal compounds mostly depends on the multi-components overall contributions.

关 键 词：药代动力学 补阳还五汤 脑健片 阿魏酸 洋川芎内酯A 藁本内酯 

分 类 号：R285.5[医药卫生—中药学]