甲状腺癌相关危险因素分析  

Risk Factors Associated with Thyroid Carcinoma

作　　者：陈志丹[1] 陈德杰[1] 程瑾[1] 

机构地区：[1]襄阳市中心医院,湖北理学院附属医院,湖北襄阳441021

出　　处：《中国肿瘤》2016年第6期433-437,共5页China Cancer

基　　金：国家自然科学基金项目(81202539)

摘　　要：[目的]分析甲状腺癌患者的临床及病理学特点,并探讨甲状腺癌的相关危险因素。[方法 ]收集行初次手术切除的316例甲状腺癌患者纳入病例组,按性别、年龄、籍贯等因素匹配后,以同期住院的非甲状腺癌患者作为对照组,收集两组患者的临床病理、生活方式、家族史等资料,采用多因素Logistic回归模型分析甲状腺癌的危险因素。[结果]不同性别的甲状腺癌病例类型分布比较差异无统计学意义（P=0.306）。男性甲状腺癌患者的平均发病年龄低于女性患者（44.4±8.8岁vs.46.9±9.4岁,P=0.047）,男、女患者的发病年龄高峰均为30-59岁。多因素Logistic回归分析显示：甲状腺疾病家族史（OR=7.156）、肿瘤家族史（OR=8.917）、BMI增高（OR=2.221）、经常性摄入海产品（≥3次/周）（OR=3.377）、甲状腺自身抗体增高（OR=2.904）是甲状腺癌的独立危险因素。[结论]女性甲状腺癌的发病率高于男性,发病高发年龄为30-59岁;甲状腺疾病家族史、肿瘤家族史、BMI增高、经常性摄入海产品（≥3次/周）、甲状腺自身抗体增高是甲状腺癌的独立危险因素。[Purpose] To analyze the clinicalpathological feature of thyroid carcinoma and to explore the risk factors of thyroid cancer. [Methods] A total of 316 patients with thyroid cancer underwent first exairesis as the case group,another 162 patients without thyroid cancer as the control group matched in age,gender,and location were enrolled in the study. The clinical and pathological material,life type and family history data were collected,multi-factor Logistic regression analysis was used to analyze the risk factors associated with thyroid cancer. [Results] The average age of thyroid cancer in male patients was lower than that in female patients（44.4 ±8.8 vs. 46.9±9.4,P=0.047）,the peak age occurrence of thyroid cancer was 30 to 59 years-old in both sexes. Multivariate Logistic regression analysis showed that a family history of thyroid disease（OR=7.156）,family history of cancer（OR=8.917）,BMI increased（OR=2.221）,regular intake of seafood（≥3times/week）（OR=3.377）,elevated thyroid autoantibodies（OR=2.904） were independent risk factors of thyroid cancer.[Conclusion] The incidence of thyroid cancer in women is higher than that in men,the peak occurrence age of thyroid cancer is 30 to 59 years. The family history of thyroid disease,family history of cancer,higher BMI,regular intake of seafood（≥3 times/week）,elevated thyroid autoantibodies may be independent risk factors of thyroid cancer.

关 键 词：甲状腺癌 病例对照研究 危险因素 

分 类 号：R736.1[医药卫生—肿瘤]