新型食管内放射支架与普通覆膜食管支架在中晚期食管癌姑息治疗中的应用  

Application of Conventional Stents and Stents Coating with ^(125)Iodinemembrane for the Treatment of Unresectable Esophageal Cancer

作　　者：贺舜[1] 张月明[1] 窦利州[1] 刘勇 刘晓[1] 于新颖[1] 王贵齐[1] 

机构地区：[1]国家癌症中心/中国医学科学院北京协和医学院肿瘤医院,北京100021

出　　处：《中国肿瘤》2016年第6期483-486,共4页China Cancer

基　　金：十二五国家科技支撑计划(2013BAI010B02002)

摘　　要：[目的]对照普通覆膜食管支架,观察食管内放射支架临床应用的有效性。[方法]2008~2010年间,对来自中国医学科学院北京协和医学院肿瘤医院等7家医院的71例不可手术切除食管癌患者,采用随机对照的研究方法,将其分为两组,对照组植入普通覆膜食管支架,研究组植入食管内放射支架,观察两组患者消化道梗阻缓解状况、支架周围肉芽组织增生情况、总生存期以及不良事件的发生情况。[结果]研究组患者消化道梗阻缓解状况明显优于对照组;而支架周围肉芽组织增生情况研究组则明显轻于对照组;中位生存期研究组亦明显长于对照组(145天vs 90天);研究组与对照组相比,不良事件发生率并不高于对照组。[结论]食管内放射支架临床应用安全、有效,是一种较为安全的晚期食管癌姑息治疗方法。[Purpose] To evaluate the efficacy of stents coating with125 iodine membrane in the palliative treatment of unresected esophageal cancer. [Methods] A total of 71 patients were rolled from 7 hospitals around the country including Chinese Academy of Medical Sciences Cancer Hospital from 2008 to 2010. By a randomized controlled method,the patients were divided into two groups,control group with a conventional stent implantation,observation group with a stents coating with125 iodine membrane implantation. Indicators including dysphagiaremission,peri-stent granulation tissue hyperplasia,overall survival and adverse events were observated. [Results] The observation group got a significant better dysphagiaremission than that in control group. A lighter degree of granulation tissue proliferation can be found in observation group compared to control group;Median overall survival in the observation group was longer than that in control group（145days versus 90 days）. Adverse events of the treatment occurred rate was lower in the observation group than that in control group. [Conclusion] The stent coating with125 iodine membrane is a safe and effective palliative treatment for patients with unersected advanced esophageal cancer,partly superior to the conventional stents.

关 键 词：食管癌 支架 放射治疗 

分 类 号：R735.1[医药卫生—肿瘤]