下颌截骨术对兔颌骨非术区骨改建的影响  

Mechanism of Action and Morphologic Changes in the Mandible in Response to Surgery-First Approach: a Rabbit Model

作　　者：黄丹青[1] 康非吾[1] 周小康[1] 吴情[1] 纪映辰 王伟伟[1] 马嘉磊 

机构地区：[1]同济大学口腔医学院.同济大学附属口腔医院口腔颌面外科上海牙组织修复与再生工程技术研究中心,上海200072

出　　处：《口腔颌面外科杂志》2016年第2期83-87,共5页Journal of Oral and Maxillofacial Surgery

摘　　要：目的 :研究正颌手术对非手术区骨组织改建的影响,以更好地了解正颌手术加速颌骨改建的机制。方法 :12只新西兰大白兔随机分成4组,每组3只,9只行"双下颌骨磨牙区矢状截骨术"为手术组,3只为对照组。手术组9只按处死时间点分为术后1周组、3周组和8周组。每只动物单侧下颌骨用于Micro-CT扫描,对侧下颌骨用于组织学观察。结果:术后下颌骨整个骨组织发生吸收,在术后3周骨丧失最为显著,在术后8周骨形态恢复到近似对照组。下颌骨前牙区(非手术区)在术后1周至3周骨吸收较对照组活跃,表现为骨皮质内血管增生,出现破骨细胞和骨吸收陷窝,在术后3周达到高峰;在术后8周骨组织则与对照组无异。结论:正颌手术后,颌骨先是骨吸收活跃伴破骨细胞增多,骨改建加速,随后新骨生成,骨组织恢复。Objective： To study the impact of mandibular osteotomy on bone remodeling. Methods： 12 rabbits were randomly and equally divided into 4 groups. Animals in 3 experiment groups were treated by bilateral mandibular osteotomy, the last group was control. The rabbits in experiment groups were sacrificed on 1-week, 3-week, and 8-week respectively. 3 mandible bone of each group were used for Micro-CT scanning, the other 3 mandible bones were used for histological examination. Results： The bone density of the whole mandible had reduced obviously on 3-week, in addition with a higher count of osteoclasts appeared in alveolar bone of incisor region. On 8-week, bone morphology recovered and showed similarity with the control group. Conclusion： Mechanism of regional acceleratory phenomenon may be related to enhancement of osteoclast differentiation and reduction of bone density.

关 键 词：骨改建 截骨术 破骨细胞 局部骨加速现象 

分 类 号：R782[医药卫生—口腔医学]