PF诱导化疗联合调强放疗及二维放疗对鼻咽癌近远期疗效影响的回顾性分析  

Retrospective analysis of the effects of PF induced chemotherapy combined with intensity modulated radiation therapy and two-dimensional radiotherapy on the short and long term curative effects in nasopharyngeal carcinoma

作　　者：李家祥[1] 程宇文 周冠群[3] 

机构地区：[1]肇庆市第一人民医院肿瘤科,肇庆526000 [2]梧州市红十字会医院放疗科,梧州543000 [3]中山大学肿瘤防治中心放疗科,广州510060

出　　处：《广州医药》2016年第3期31-33,共3页Guangzhou Medical Journal

摘　　要：目的研究PF诱导化疗联合调强放疗及二维放疗对鼻咽癌近远期疗效影响的回顾性分析。方法回顾性分析2008年1月—2008年12月中山大学附属肿瘤医院收治的101例鼻咽癌患者治疗情况,按照治疗方案技术分为调强组(n=42)和二维组(n=59)。比较两组患者临床疗效,近期毒副反应及生存情况。结果放疗结束时调强组患者总缓解率92.86%与二维组77.97%比较差异有统计学意义(P<0.05)。调强组Ⅲ-Ⅳ级胃肠道反应26.19%及黏膜炎14.29%发生率与二维组比较显著较少,差异有统计学意义(P<0.05)。两组患者远期毒副反应及生存率比较无显著差异(P>0.05)。结论 PF诱导化疗联合调强放疗治疗鼻咽癌患者,近远期临床疗效好,毒副反应少。Objective To study the effects of PF induced chemotherapy combined with intensity modulated radiation therapy and two-dimensional radiotherapy on the short and long term curative effects in nasopharyngeal carcinoma. Methods The treatment condition of 101 cases of patients with nasopharyngeal carcinoma who were treated in the Tumor Hospital Affiliated to San Yat-sen University between January and December 2008 were retrospectively analyzed. According to different treatments,the cases were divided into the intensity modulated group and the two-dimensional group. The clinical curative effects,short-term toxic and side effects and survival status were compared between the two groups. Results At the end of radiotherapy,the total remission rate in the intensity modulated group was 92. 86% while in the two-dimensional group was 77. 97%（ P 〈 0. 05）. In the intensity modulated group, the incidence rates of grade Ⅲ-Ⅳ gastrointestinal tract reactions（ 26. 19%） and mucositis（ 14. 29%） were significantly lower than those in the two-dimensional group（ P 〈 0. 05）. There was no significant difference in long-term side effects and survival rate between the two groups（ P 〉 0. 05）. Conclusion PF induced chemotherapy combined with intensity modulated radiation therapy in the treatment of patients with nasopharyngeal carcinoma has good short and long-term curative effects and few toxic and side effects.

关 键 词：PF诱导化疗 调强放疗 二维放疗 鼻咽癌 

分 类 号：R739.63[医药卫生—肿瘤]