MEN1/menin协同细胞内信号通路参与机体代谢调控  

Regulation Effects of MEN1/menin on Biologic Metabolism by Interacting with Different Intracellular Signaling Pathways

作　　者：李洪辉[1] 刘学[1] 师科荣[1] 

机构地区：[1]山东农业大学动物科技学院山东省动物生物工程与疾病防治重点实验室,山东泰安271018

出　　处：《中国畜牧杂志》2016年第11期87-92,共6页Chinese Journal of Animal Science

基　　金：国家自然科学基金(31402054);国家奶业产业技术体系资助项目(CARS-37);山东省自然科学基金(ZR2013CM013);山东省奶牛良种工程重大课题(2012LZ15);山东省泰山学者种业创新人才团队支撑计划培养项目(2014LZ07-04);山东省牛产业技术体系资助项目(SDAIT-12-011-06)

摘　　要：MEN1基因是其表现病征——多发性内分泌肿瘤Ⅰ型综合征的关键致病基因之一。该基因编码的蛋白menin不仅可以与大量关键转录因子相互作用,通过表观遗传方式调控其靶基因的转录和细胞表型,也可与大量的细胞内信号通路因子相互作用,广泛参与机体正常发育和代谢的平衡稳态调节,同时,我们的研究证明该基因的表达对于奶牛乳腺上皮细胞的生长也具有很重要的调控功能。本文综述了MEN1/menin协同不同信号通路参与机体代谢调节机制的新进展,这些新的发现将有助于我们全面了解MEN1/menin在各物种机体代谢中的调节作用;同时基于各物种间MEN1/menin的高度保守性,也将为该基因在家畜领域的研究提供必要的信息储备、新的研究思路和切入点。MEN1 gene is named by its mainly causative disease,multiple endocrine neoplasia type 1.MEN1 is its critical causative gene.Menin is its encoded protein.Menin interacts with many important transcription factors,epigenetically regulating the expression of its target gene and induced cell phenotypes,also joined different intracellular signaling pathways,widely regulating body development and metabolic stability.Our results suggest bovine MEN1 gene plays regulatory roles in mammary epithelial cell growth.Here we reviewed recent discoveries about MEN1/menin associating with cell signalings and playing different regulatory roles in tissue metabolism.These discoveries will benefit us to fully understand metabolic effects of MEN1/menin among different species because of its high conservation,more importantly,provide necessary basic information reservations,new research thoughts and entry points for future investigations of MEN1/menin in domestic animal fields.

关 键 词：MEN1基因 MENIN蛋白 信号通路 代谢调节 

分 类 号：S816.7[农业科学—饲料科学]