丁苯酞联合奥扎格雷钠治疗短暂性脑缺血发作的疗效观察  

Curative effect of butylphthalide and ozagrel on transient ischemic attack

作　　者：张绒[1] 代昌飞 何晓琛 

机构地区：[1]延安大学咸阳医院神经内科,陕西咸阳712000 [2]西安交通大学第一附属医院,陕西西安710061

出　　处：《西部医学》2016年第6期797-799,共3页Medical Journal of West China

基　　金：国家自然科学基金(81272300);陕西省国际合作项目(2011KW-47)

摘　　要：目的观察丁苯酞软胶囊联合奥扎格雷钠注射液治疗短暂性脑缺血发作患者的临床疗效。方法选择2010年7月-2015年2月我院神经内科收治的短暂性脑缺血发作住院患者124例,按照数字表法随机分为观察组和对照组各62例。两组患者均行降压降糖以及低分子肝素、维生素C、尼莫地平、抗感染等常规治疗,对照组患者在常规治疗基础上,给予奥扎格林钠注射液治疗,观察组患者在对照组基础上加用丁苯酞软胶囊治疗,治疗周期均为2周。治疗结束时对比两组患者治疗前后血液流变学指标和脑氧代谢指标的变化情况。结果两组患者临床总有效率比较,观察组为90.32%,对照组为66.13%,观察组明显高于对照组,差异有统计学意义（P〈0.05）;观察组的血液流变学指标和脑氧代谢指标改善情况均明显优于对照组,差异均有统计学意义（均P〈0.05）。结论应用丁苯酞软胶囊联合奥扎格雷钠注射液治疗短暂性脑缺血发作较单用奥扎格雷钠注射液疗效显著,可改善短暂性脑缺血发作患者血液流变学和脑氧代谢病态状况。Objective To study the curative effect of butylphthalide and ozagrel on transient ischemic attack.Methods 124in-patients with transient ischemic attack were randomly divided into observation group（62cases）and control group（62cases）.The two groups were treated with routine therapy including low molecular heparin,vitamin C,Nimodipine and anti-infection.The control group was treated with ozagrel and the observation group with ozagrel and butylphthalide,additionally.The blood rheological index and cerebral oxygen metabolism index were observed.Results The total effective rate of observation group（90.32%）was higher than that of the control group（66.13%）（P〈0.05）.The hemorheology index and cerebral oxygen metabolism index of observation group more obviously improved than that of the control group（P〈0.05）.Conclusion Short-term application of butylphthalide and ozagrel on treatment of transient ischemic attack can significantly improve hemorheology in patients with transient ischemic attack and cerebral oxygen metabolism pathological conditions.

关 键 词：丁苯酞 奥扎格雷钠 短暂性脑缺血发作 血液流变学 脑氧代谢 

分 类 号：R743.31[医药卫生—神经病学与精神病学]