西妥昔单抗联合FOLFOX4对老年结肠癌患者组织PTEN及P13K表达的影响  

Effect of cetuximab combined with FOLFOX4 on expressions of PTEN and P13K in colon cancer tissue of elderly patients

作　　者：虞义建[1] 虞玲燕 王双珠[1] 

机构地区：[1]浙江省台州医院病理科,浙江台州317000 [2]浙江省台州医院急诊科,浙江台州317000

出　　处：《中国生化药物杂志》2016年第4期158-160,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江省自然科学基金(LY13H160024)

摘　　要：目的探讨西妥昔单抗联合FOLFOX4化疗方案对老年结肠癌患者组织抑癌基因PTEN及P13K表达的影响。方法选取2013年10月~2015年7月浙江省台州医院收治的结肠癌老年患者62例,按治疗方法不同分组,对照组（n=27）采用单纯FOLFOX4方案化疗,研究组（n=35）在FOLFOX4化疗方案基础上给予西妥昔单抗治疗,疗程均为4个周期,对比2组间临床疗效,治疗前后采用免疫组化测定病理组织PTEN及P13K表达状况。结果研究组有效率（51.4%）与对照组有效率（44.4%）,研究组疾病控制率（80.0%）与对照组疾病控制率（62.9%）比较差异均无统计学意义（χ2=0.298,P=0.585;χ2=2.223,P=0.136）。在组织PTEN及P13K表达上,研究组治疗后PTEN阳性率显著高于对照组（82.86%vs.59.26%,P〈0.05）,治疗后P13K阳性率显著低于对照组（37.14%vs.62.96%,P〈0.05）。结论采用西妥昔单抗联合FOLFOX4化疗方案治疗老年结肠癌能提高组织PTEN表达,降低P13K表达,效果显著。Objective To investigate the effect of cetuximab combined with FOLFOX4 chemotherapy on expressions of cancer suppressor gene PTEN and P13 K in colon cancer tissue of elderly patients. Methods 62 cases of elderly patients with colon cancer from October 2013 to July 2015 in our hospital were selected and divided into two groups according to the different therapy. The control group（ n = 27） received pure FOLFOX4 chemotherapy and treatment group（ n = 35） received cetuximab on the basis of FOLFOX4 chemotherapy,with a consecutive treatment of 4 courses. The clinical curative effect and expressions of PTEN and P13 K in colon cancer tissue were compared between two groups. Results There were no significant difference in effective rate and disease control rate between treatment group and control group（ 51. 4% vs. 44. 4%,χ2= 0. 298,P = 0. 585; 80. 0% vs. 62. 9%,χ2=2. 223,P = 0. 136）. After treatment,the cells positive rate of PTEN in treatment group was higher than that in control group post-treatment（ 82. 86%vs. 59. 26%,P〈0. 05）,and the cells positive rate of P13 K in treatment group was lower than that in control group（ 37. 14% vs. 62. 96%,P〈0. 05）.Conclusion Cetuximab combined FOLFOX4 chemotherapy regimen could increase expression of PTEN and reduce P13 K expression,which effect is remarkable in the treatment of elderly colon cancer.

关 键 词：西妥昔单抗 FOLFOX4 老年 结肠癌 PTEN P13K 

分 类 号：R735.35[医药卫生—肿瘤]