分子成像与肿瘤靶向治疗  

Molecular imaging and tumor targeted therapy

作　　者：孙夕林[1,2] 韩兆国 吴泳仪 申宝忠[2] 

机构地区：[1]哈尔滨医科大学附属第四医院TOF-PET/CT/MR中心,哈尔滨市150028 [2]哈尔滨医科大学分子影像研究中心

出　　处：《中国肿瘤临床》2016年第11期475-479,共5页Chinese Journal of Clinical Oncology

基　　金：国家重点基础研究发展计划(编号:2015CB931800);国家自然科学基金项目(编号:81471724;81101088;81130028;31210103913);黑龙江省自然科学基金委留学归国科学基金(编号:LC2013C26);黑龙江省级领军人才梯队后备带头人资助资金;哈尔滨市科技创新人才研究专项资金(编号:2014RFQGJ011);哈尔滨医科大学伍连德青年科学基金(编号:WLD-QN1119);哈尔滨医科大学附属第四医院杰出青年基金;黑龙江省高校分子影像重点实验室基金资助~~

摘　　要：肿瘤关键分子靶点的异常表达(表达水平和表达状态)与分子靶向治疗反应、治疗效果及预后密切相关。因此,精准评价肿瘤关键分子表达水平和表达状态,无论在肿瘤分子靶向治疗开展前、过程中以及治疗后均显得尤为关键。分子成像可以无创、实时而全面地对肿瘤关键靶点的表达水平及表达状态进行定性、定量研究,对筛选优势人群、指导治疗、判断预后具有重大意义。本文简述基于不同分子探针的分子成像技术在肿瘤靶向治疗过程中的应用,对比分析分子成像在靶向治疗中的价值,以期有益于新型治疗策略的开发。The abnormal expression （level and status） of the key molecular targets of tumors is related to molecular targeted therapy response, effect, and prognosis. Therefore, the expression level and status of key molecular targets of tumors must be accurately evalu-ated, regardless of the status before, during, and after receiving targeted therapy. Molecular imaging is a non-invasive method used for qualitative and quantitative research on key molecular targets of tumor in vivo and in real-time. This technique is also employed to screen treatment beneficiaries, guide therapy, and evaluate prognosis. This paper reviews the application progress of molecular imag-ing using various probes in cancer targeted therapy. The clinical value of molecular imaging in tumor targeted therapy is further ana-lyzed to promote the development of novel targeted therapy for tumors.

关 键 词：分子成像 临床应用 肿瘤分子靶向治疗 

分 类 号：R730.5[医药卫生—肿瘤]