S100A3在胃癌组织中表达及临床意义  

Expressions and clinical significance of S100A3 in gastric cancer

作　　者：刘骥[1] 李雪[1] 李纪鹏[2] 王为忠[2] 

机构地区：[1]空军杭州航空医学鉴定训练中心,杭州310013 [2]第四军医大学西京医院消化病医院消化三科,西安710032

出　　处：《空军医学杂志》2016年第2期91-93,共3页Medical Journal of Air Force

摘　　要：目的分析S100A3在胃癌中表达情况及临床意义。方法采用逆转录-聚合酶链反应、蛋白质印迹和组织微阵列分析90例胃癌组织及正常胃组织标本和胃癌细胞系中S100A3基因、蛋白表达水平及组学定位。结果胃癌组织S100A3基因表达水平高于正常胃组织2.5倍,S100A3的上调表达与肿瘤分化程度、TNM分期相关,胃癌细胞S100A3基因呈上调表达。胃癌组织中S100A3蛋白表达水平强阳性表达(74.7%)。结论 S100A3上调表达与胃癌分化程度及TNM分期密切相关。Objective To explore the expression and clinical significance of S100A3 within gastric cancer.Methods Combined with analysis of RT-PCR,Western blot and Tissue microarray（TMA）,the mRNA and protein expression levels of S100A3 in normal and malignant stomach tissues and cell lines were systematically investigated.Results The mean expression levels of S100A3 in gastric cancer tissues were 2.5 times as high as in adjacent nontumorous tissues.S100A3 expression was correlated with tumor differentiation and TNM stage of gastric cancer.S100A3 was overexpression in gastric cancer cell lines.The mean expression levels of S100A3 protein in gastri cancer were higher.Conclusion Overexpressed S100A3 may be associated with the differentiation and progression of gastric cancer.

关 键 词：胃癌/病理学 S100A3 肿瘤分化 肿瘤淋巴结转移 

分 类 号：R735.2[医药卫生—肿瘤]