吲哚菁绿在乳腺癌前哨淋巴结活检中的应用  

Application of indocyanine green in sentinel lymph node biopsy for breast cancer

作　　者：唐巍[1] 张显岚[1] 曾繁余[1] 

机构地区：[1]桂林医学院附属医院乳腺外科,广西桂林541000

出　　处：《局解手术学杂志》2016年第6期395-397,共3页Journal of Regional Anatomy and Operative Surgery

基　　金：广西壮族自治区卫生厅项目(Z2013469);桂林市科技局项目(20140120-1-10)

摘　　要：目的探讨吲哚菁绿(ICG)在乳腺癌前哨淋巴结活检(SLNB)中的应用价值。方法对我院2013年1月至2015年12月160例乳腺癌患者进行检测分析,随机分为亚甲蓝组、亚甲蓝联合吲哚菁绿组,分别为65例和95例。比较2组患者的检出成功率、准确率和假阴性率。结果亚甲蓝联合吲哚菁绿组的检出成功率和准确性明显高于亚甲蓝组,差异具有统计学意义(P<0.05);亚甲蓝联合吲哚菁绿组的假阴性率明显低于亚甲蓝组,差异具有统计学意义(P<0.05);亚甲蓝联合吲哚菁绿组检出的前哨淋巴结(2.9±0.9)枚/例,明显多于亚甲蓝组(1.9±0.5)枚/例,差异具有统计学意义(P<0.05);亚甲蓝联合吲哚菁绿组的手术用时明显短于亚甲蓝组。结论吲哚菁绿应用于乳腺癌前哨淋巴结检测可降低其假阴性率,提高乳腺癌的诊断水平。Objective To explore the application value of indocyanine green （ICG）in sentinel lymph node biopsy（SLNB）for breast cancer.Methods A total of 160 patients with breast cancer in our hospital from January 2013 to December 2015 were analyzed,who were randomly divided into methylene blue group（n =65）and methylene blue plus ICG group（n =95）.The success rate of detection,accuracy and false negative rate between two groups were compared.Results The success rate of detection and accuracy in methylene blue plus ICG group was significantly higher than thoase in methylene blue group,with statistically significant difference（P 〈0.05）.The false negative rate of methylene blue plus ICG group was significantly lower than that of methylene blue group,with statistically significant difference （P 〈0.05）.The number of sentinel lymph node in methylene blue plus ICG group was （2.9 ±0.9）/case which was more than （1.9 ± 0.5）/case in methylene blue group ,with statistically significant difference（P 〈0.05）.The length of opertion of methylene blue plus ICG group was obviously shorter than that of methylene blue group.Conclusion Indocyanine green used in the sentinel lymph node detection for breast cancer can provide a reliable basis and reduce the false negative rate,who improves the level of diagnosis of breast cancer.

关 键 词：吲哚菁绿 乳腺癌 前哨淋巴结 活检 

分 类 号：R737.9[医药卫生—肿瘤]