国人肺癌骨转移对血清骨钙素水平影响的Meta分析  

Effect of lung cancer bone metastasis on serum osteocalcin levels in Chinese population: a meta-analysis of casecontrol studies

作　　者：臧乐源[1] 马敏[1] 胡建新[1] 邱浩[1] 黄博[1] 初同伟[1] 

机构地区：[1]第三军医大学新桥医院骨科,重庆400037

出　　处：《局解手术学杂志》2016年第6期442-445,共4页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的通过Meta分析评价国人肺癌骨转移对血清骨钙素(OC)水平的影响。方法检索Pub Med、Web of science、Embase、Cochrane Library、中国生物医学文献数据库、中国期刊全文数据库、维普及万方数据库中关于研究中国人群肺癌骨转移对血清骨钙素水平影响的文献,并用SMD(标准化均数差)及其相应95%CI对结果进行评价。结果最终纳入文献8篇。Meta分析结果提示,与正常对照人群(Controls)和肺癌非骨转移人群(BM-)相比,肺癌骨转移(BM)时血清中骨钙素水平明显升高,SMD(95%CI)分别为0.58[0.15,1.01]和0.77[0.20,1.34],差异有统计学意义;而肺癌非骨转移时血清骨钙素水平与正常对照组相比无统计学差异,SMD(95%CI)为-0.15[-0.54,0.23])。结论国人血清中骨钙素含量升高与肺癌骨转移有一定关系,而未发生骨转移肺癌人群血清骨钙素水平无明显变化。Objective To evaluate the effect of lung cancer bone metastasis on serum osteocalcin（OC）in Chinese population using me-ta-analysis.Methods Searched the date of PubMed,Web of science,Embase,Cochrane Library,CBM,CNKI,VIP database and Wanfang da-tabase to identify potentially studies which involved the correlation between bone metastasis and serum OC in Chinese patients with lung canc-er.Standardized mean difference（SMD）and 95%CI was used to access the results.Results 8 studies were included.The study showed that the OC in serum would increase significantly when bone metastases happened in Chinese lung cancer patients.SMD（95%）CI was 0.58 [0.15,1.01]and 0.776[0.20,1.34]compared with controls and BM-,respectively.SMD and 95%CI of BM-compared with controls was -0.15[-0.54,0.23],insignificantly.Conclusion Lung cancer bone metastases may raise serum osteocalcin levels in Chinese popu-lation meanwhile this phenomenon will not happen without bone metastasis.

关 键 词：骨钙素 肺癌 骨转移 META 分析 

分 类 号：R738.1[医药卫生—肿瘤] R734.2[医药卫生—临床医学]