萃取纳升喷雾-离子迁移谱法现场快速筛查化妆品中8种禁用抗生素  

Rapid on-site screening of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrometry

作　　者：孟宪双[1] 马强[1] 马龙华 陈丽华[3] 韩超 白桦[1] 吴青 

机构地区：[1]中国检验检疫科学研究院,北京100176 [2]Excellims Corporation, Acton, MA 01720, USA [3]重庆出入境检验检疫局,重庆400020 [4]温州出入境检验检疫局,浙江温州325027

出　　处：《色谱》2016年第6期596-601,共6页Chinese Journal of Chromatography

基　　金：国家质检总局科技计划项目(2015IK314);中央级公益性科研院所基本科研业务费专项资金资助项目(2016JK004)~~

摘　　要：采用萃取纳升喷雾结合离子迁移谱技术,建立了化妆品中8种禁用抗生素的现场快速筛查方法。对萃取纳升喷雾毛细管拉制条件、萃取纳升喷雾离子化条件、离子迁移谱检测条件等进行了详细考察和优化。在优化的实验条件下,8种禁用抗生素的方法检出限为20 mg/kg,离子迁移谱分析时间小于20 ms,单个样品全部检测时间不超过30 s。对于筛检出的疑似阳性样品,进一步采用超高效液相色谱-串联质谱进行确证。该方法流程简便、快捷高效,为化妆品中违禁组分的现场快速筛查提供了较为广阔的应用前景。A rapid on-site method has been developed for the identification of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrometry. The experimental conditions for capillary pulling,extraction nano-electrospray,and ion mobility spectrometry were investigated and optimized. Under the optimum conditions,the limits of detection（LODs）for the eight prohibited antibiotics were 20 mg / kg. The instrumental analysis time for a single ion mobility spectrometry run was less than 20 ms,and the total period for sample analysis was less than 30 s. The suspicious positive samples were subjected to further verification by ultra-performance liquid chromatography-tandem mass spectrometry（UPLC-MS/ MS）. The proposed method is rapid,efficient with greatly simplified work flows and can provide potential analytical possibility for outside-the-lab screening of cosmetics for the presence of illicit ingredients.

关 键 词：萃取纳升喷雾 离子迁移谱 禁用抗生素 化妆品 现场快速筛查 

分 类 号：O658[理学—分析化学]