MALDI-TOF-MS检测分枝杆菌属正确率的荟萃分析  

Meta-analysis of MALDI-TOF-MS in detection of Mycobacterium

作　　者：郭旭光[1] 林翠琼[2] 邓穗燕[1] 林丽英[1] 陈琼[1] 陈金桃[1] 夏勇[1] 

机构地区：[1]广州医科大学附属第三医院检验科,广州510150 [2]广州医科大学金域检验学院,广州510182

出　　处：《临床检验杂志》2016年第3期233-236,共4页Chinese Journal of Clinical Laboratory Science

摘　　要：目的对MALDI-TOF MS快速检测分枝杆菌属的正确率进行荟萃(meta)评价。方法收集1990-2015年,国外公开发表的关于MALDI-TOF MS检测分枝杆菌的文献,按meta分析的要求对文献进行检索、筛选,对纳入的文献进行质量评价,对符合条件的研究进行meta分析。结果共有11篇文献纳入,对各文献的研究进行数据提取后合并MALDI-TOF MS鉴定分枝杆菌属的正确率,结果正确率为91%。结论 MALDI-TOF MS对分枝杆菌属的鉴定有较好的准确性。Objective To evaluate the accuracy of matrix-assisted laser desorption / ionization time of flight mass spectrometry（ MALDI-TOF MS） in rapid identification of Mycobacterium by Meta-analysis. Methods All the published literatures on Mycobacterium detected by MALDI-TOF MS were collected from 1990 to 2015. The methodological quality of the enrolled studies was evaluated according to Quality Assessment of Diagnostic Accuracy Studies（ QUADAS）. A meta-analysis for all the eligible studies was performed. The correct rate of MALDI-TOF MS in identifying Mycobacterium was calculated. Results A total of 11 articles were enrolled and all the data was extracted and combined. The correct rate of MALDI-TOF MS for identification of Mycobacterium was 91%. Conclusion MALDI-TOF MS exhibited high accuracy for identification of Mycobacterium.

关 键 词：基质辅助激光解吸电离飞行时间质谱 质谱 分枝杆菌 荟萃分析 

分 类 号：R446.5[医药卫生—诊断学]