异甘草酸镁联合双环醇治疗化疗药物性肝损害的疗效观察  

Observation of therapeutic efficacy of magnesium isoglycyrrhizinate plus bicyclol for chemotherapy drugs-induced liver injury

作　　者：王艳华[1] 刘冬兰[1] 

机构地区：[1]江西省肿瘤医院内三科,南昌330029

出　　处：《江西医药》2016年第5期405-407,共3页Jiangxi Medical Journal

摘　　要：目的探讨异甘草酸镁联合双环醇治疗化疗药物性肝损害的疗效。方法 80例化疗药物性肝损害患者被随机分为对照组与实验组,2组患者各40例,对照组接受常规护肝治疗,实验组使用异甘草酸镁联合双环醇护肝治疗,治疗1周后进行疗效及不良反应评价。结果⑴治疗前,2组患者总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)、前白蛋白(PA)、拟乙酰胆碱酯酶(PCHE)相比差异无统计学意义(P>0.05)。治疗1周后,实验组TBIL、ALT、AST、GGT、ALP显著低于对照组,PA、PCHE显著高于对照组,差异有统计学意义(P<0.05)。⑵经疗效评价,实验组治疗效果显著优于对照组,差异有统计学意义(P<0.05)。⑶2组患者不良反应发生率相比差异无统计学意义(P>0.05)。结论异甘草酸镁联合双环醇治疗化疗药物性肝损害具有疗效可靠、安全性好等优点。Objective To investigate the therapeutic efficacy of magnesium isoglycyrrhizinate plus bicyclol in the treatment of patients with chemotherapy drugs-induced liver injury. Methods 80 cases of chemotherapy drugs-induced liver injury were divided into a control group and an experimental group randomly,and there were 40 cases of patients in each group. The control group was given conventional liver-protecting therapy,while the experimental group received magnesium isoglycyrrhizinate plus bicyclol.The therapeutic efficacy and adverse reactions were evaluated after 1-week therapy. Results ⑴ Before treatment,no statistical differences were found in total bilirubin（TBIL）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,γ-glutamyltransferase（GGT）,alkaline phosphatase（ALP）,pre- albumin（PA）,pseudocholinesterase（PCHE） between the 2 groups（P〈0.05）. After 1-week therapy,the TBIL,ALT,AST,GGT,ALP in experimental group were statistically lower than those in control group,while the PA and PCHE were statistically higher than those in control group（P〈0.05）. ⑵After evaluation of therapeutic efficacy,the efficacy in experimental group was superior to that in control group（P〈0.05）. ⑶No statistical difference was found in incidence of adverse reactions between the 2 groups（P〉0.05）. Conclusion The magnesium isoglycyrrhizinate plus bicyclol for chemotherapy drugs-induced liver injury shows reliable efficacy and good safety.

关 键 词：异甘草酸镁 双环醇 化疗药物性肝损害 

分 类 号：R730.53[医药卫生—肿瘤]