鼻咽癌组织中程序性死亡受体-1的表达和临床意义  

Clinical significance of the expression of programmed death-1 in nasopharyngeal carcinoma

作　　者：李鹰飞[1,2] 丁剑午[1] 黄龙[1] 

机构地区：[1]南昌大学第二附属医院肿瘤科,南昌330006 [2]江西省抚州市第一人民医院肿瘤内科,抚州344000

出　　处：《江西医药》2016年第5期408-410,共3页Jiangxi Medical Journal

基　　金：国家自然科学基金(81460393和81460449);江西省自然科学基金(20142BAB215039和20151BAB215020);江西省科技计划项目(20141BBG70041);江西省教育厅科技计划项目(GJJ14059);南昌大学第二附属医院青年基金(2014YNQN12004)

摘　　要：目的探讨鼻咽癌组织中程序性死亡受体-1(PD-1)的表达与鼻咽癌患者临床病理特征及预后关系。方法应用免疫组化方法检测120例鼻咽癌组织中PD-1的表达,收集对应鼻咽癌患者临床病理特征资料,随访得到患者无疾病进展时间及总生存时间。结果鼻咽癌组织中PD-1的表达与患者年龄、性别、病理类型、分期及淋巴结转移无关,与吸烟可能有关。经常规放化疗后,相比PD-1阳性鼻咽癌患者,PD-1阴性鼻咽癌患者无疾病进展时间无明显差异(P=0.191),总生存时间明显延长(P=0.002)。结论鼻咽癌组织中PD-1的检测对鼻咽癌患者预后及治疗可能有一定的指导意义。Objective To investigate the expression of PD-1 in nasopharyngeal carcinoma and their relationship with the clinicopathological characteristics and prognosis of patients with nasopharyngeal carcinoma. Methods The expression of PD-1 was detected by immunohistochemistry method in 120 cases of nasopharyngeal carcinoma tissue. Meanwhile,To collect the corresponding data of clinical and pathological features of nasopharyngeal carcinoma patients,follow up patients for disease free survival and overall survival. Results The expression of PD-1 in nasopharyngeal carcinoma tissue was not related to age,sex,pathological type,stage and lymph node metastasis,but probably related to smoking. After conventional chemoradiotherapy,There was no significant difference in disease-free survival（P=0.191） in nasopharyngeal carcinoma patients with PD-1 negative and PD-1 positive.,but overall survival was significantly prolonged in PD-1 negative nasopharyngeal carcinoma patients（P=0.002）. Conclusion Detection of PD-1 in nasopharyngeal carcinoma tissue has probably guiding significance for the prognosis and treatment of patients with nasopharyngeal carcinoma.

关 键 词：鼻咽癌 程序性死亡受体-1 临床意义 

分 类 号：R739.63[医药卫生—肿瘤]