甲状腺乳头状癌女性患者血清25-羟维生素D和触珠蛋白的水平及其临床意义  

Serum 25-hydroxy Vitamin D and Haptoglobin Levels in Female Patients with Papillary Thyroid Carcinoma and Its Clinical Significance

作　　者：叶健波[1] 

机构地区：[1]广西贵港市人民医院,537100

出　　处：《实用癌症杂志》2016年第6期901-904,共4页The Practical Journal of Cancer

摘　　要：目的观察甲状腺乳头状癌女性患者血清25-羟维生素D和触珠蛋白的水平及与临床病理因素间的相关性。方法选择甲状腺乳头状癌女性患者共31例,同期纳入体检健康者40例为对照组。测定2组血清25-羟维生素D和触珠蛋白水平;分析血清25-羟维生素D和触珠蛋白表达水平与患者的年龄、肿瘤直径大小、TNM分期及淋巴结转移等临床病理参数的相关性。所有患者行3年期随访,比较存活患者与死亡患者血清25-羟维生素D和触珠蛋白水平。结果与对照组比较,甲状腺乳头状癌组血清25-羟维生素D水平明显降低,而触珠蛋白明显升高,比较差异均有统计学意义(P<0.01)。血清25-羟维生素D和触珠蛋白的表达水平与甲状腺乳头状癌的患者年龄、肿瘤直径大小无明显相关性(P>0.05),而与甲状腺乳头状癌的TNM分期、淋巴结转移呈明显相关(P<0.01)。3年期内死亡患者入院时血清25-羟维生素D水平明显低于存活组,触珠蛋白水平明显高于存活组,比较差异有统计学意义(P<0.01)。结论甲状腺乳头状癌患者血清25-羟维生素D水平明显降低,而触珠蛋白水平明显升高,与甲状腺乳头状癌的恶性程度呈明显性相关,可能是甲状腺乳头状癌患者预后的重要评价指标。Objective To study the serum 25-hydroxy vitamin D and haptoglobin levels in female patients with papillary thyroid carcinoma and its correlation with clinicopathological parameters. Methods 31 patients with papillary thyroid carcinoma were the study group,and 40 cases of healthy patients were the control group. Serum 25-hydroxy vitamin D and haptoglobin levels were detected in the 2 groups. Correlation of serum 25-hydroxy vitamin D and haptoglobin levels and clinicopathological parameters such as age,tumor diameter,TNM stage and lymphatic metastasis were analyzed. All patients were given 3-years follow-up.Serum 25-hydroxy vitamin D and haptoglobin levels were compared between survival and death group. Results Compared with the control group,serum level of 25-hydroxy vitamin D of the study group obviously decreased,and haptoglobin obviously increased,there had statistical difference（ P〈0. 01）. Serum 25-hydroxy vitamin D and haptoglobin levels had no significant correlation with age and tumor diameter（ P〉0. 05）,but had significant correlation with TNM stage and lymph node metastasis（ P〈0. 01）. Serum 25-hydroxy vitamin D levle of death group on admission were obviously lower than that of survival group,while level of haptoglobin were evidently higher than that of survival group,there had statistical difference（ P〈0. 01）. Conclusion Serum25-hydroxy vitamin D levels in papillary thyroid carcinoma are obviously lower while level of haptoglobin is evidently higher,which are closely related with malignancy grade,and it could be important prognostic indicator in evaluating prognosis.

关 键 词：甲状腺乳头状癌 女性 25-羟维生素D 触珠蛋白 相关性 

分 类 号：R736.1[医药卫生—肿瘤]