脂肪代谢与肿瘤  

Lipid Metabolism and Cancer

作　　者：梁蓓蓓[1,2] 薛邦德[3] 刘箐[2] 陈锐[4] 何培忠[1] 

机构地区：[1]上海健康医学院医学影像学院,上海200933 [2]上海理工大学系统生物研究中心,上海200933 [3]上海交通大学附属瑞金医院心脏外科,上海200025 [4]第二军医大学国际肿瘤研究所,上海200433

出　　处：《肿瘤防治研究》2016年第6期531-533,共3页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81402030);上海市青年教师资助计划项目(slg14064)

摘　　要：脂肪代谢是机体内非常重要的代谢途径之一,其在细胞内环境稳态的维持上发挥着不可忽视的作用。机体脂肪代谢主要由脂肪酸代谢和脂滴代谢组成。越来越多的研究显示脂肪代谢与肿瘤的发生发展有着一定的关系,其中脂肪酸代谢对于恶性肿瘤微环境的维持至关重要,而脂滴代谢更是参与了多种恶性肿瘤的发生和发展。本文就脂肪代谢与肿瘤之间的关系及其相关机制作一综述,探讨脂肪代谢在肿瘤研究中的作用和意义。Lipid metabolism is one of the most important metabolic pathways in the organism, and it plays central roles in the homeostasis. Fatty acid and lipid droplets are two processes in lipid metabolism. More and more researches confirmed that it had certain relationship between lipid metabolism and the proliferation of can cers. Recent studies have demonstrated that the microenvironment of cancer cells is affected by the unsaturated lipids metabolism. Lipid droplets proteins are involved in the occurrence and development of malignant tumors. In this review, we will summarize the relationship between lipid metabolism and cancer development, and the potential mechanism under them, and explore the significance of lipid metabolism and cancer.

关 键 词：肿瘤 脂肪代谢 脂肪酸 脂滴 

分 类 号：R730[医药卫生—肿瘤]