Effects of MK-801 and Schizandrol A on DA/DOPAC Measured by Voltammetry in Ischemic Rat Striatum  

伏安法测定MK-801和五味子醇甲对DA/DOPAC的影响

作　　者：张建军[1] 钮心懿[1] 

机构地区：[1]中国医学科学院药物研究所,北京100050

出　　处：《Journal of Chinese Pharmaceutical Sciences》1992年第2期52-58,共7页中国药学（英文版）

摘　　要：The time course of changes in the levels of extracellular DA/DOPAC in rat striatum during brain ischemia and reperfusion was measured by the method ofin vivo differential normal pulse voltammetry(DNPV).Acute cerebral ischemia of rats was pro- duced by four—vessel occlusion.The effects of(+)MK-801 and schizandrol A on the change of DA/DOPAC were investigated.The results showed that the DA/DOPAC peak in- creased markedly during 6 min of ischemia and,after reperfusion,the peak height decreased gradually.Both(+)-MK-801 and schizandrol A significantly inhibited the DA release after ischemia jn the striatum.用差示复位脉冲伏安法(DNPV)在体测定了大鼠纹状体细胞外液中DA/DOPAC含量在缺血和再灌期的动态变化,并观察了MK-801和五味子醇甲对DA/DOPAC变化的影响,结果表明缺血6分钟期间DA/DOPAC峰显著增高,再灌流后,峰高逐渐下降,(+)MK-801和五味子醇甲均能显著抑制缺血后纹状体内DA的释放。

关 键 词：ISCHEMIA VOLTAMMETRY DOPAMINE (+)MK-801 Schizandrol A 

分 类 号：R285.5[医药卫生—中药学] R364.1[医药卫生—中医学]