C反应蛋白、降钙素原、D-二聚体在社区获得性肺炎的临床意义  

C reactive protein,calcitonin and D-dimer in patients of community acquired pneumonia

作　　者：张学林[1] 王震[2] 吕淑慧[1] 荆海钧 康剑云[1] 赵建清[4] 

机构地区：[1]河北北方学院附属第二医院呼吸内科,河北张家口075100 [2]石家庄市第一医院呼吸内三科,河北石家庄050011 [3]河北省怀安县县医院内科,河北怀安075160 [4]河北北方学院附属第一医院呼吸内科,河北张家口075000

出　　处：《海南医学院学报》2016年第15期1640-1642,共3页Journal of Hainan Medical University

基　　金：张家口市科学技术和地震局计划项目(1521055D)~~

摘　　要：目的：探讨C-反应蛋白（CRP）、降钙素（PCT）、D-二聚体（D-D）在社区获得性肺炎的临床意义。方法：选取2015年3月~2016年3月我院收治的102例CAP患者为研究对象,采集CAP患者（入院24h内,接受抗生素治疗前）外周静脉血5mL,离心分离血清,免疫比浊法测定CRP、D-D,免疫荧光法测定PCT,分析CRP、PCT、D-D对CAP患者的临床意义。结果：随着分级的增加,CRP、PCT、D-D水平逐渐升高,各级间差异均有统计学意义（均P〈0.05）;重症组CRP、PCT、D-D水平明显高于非重症组,差异有统计学意义（P〈0.05）;死亡组CRP、PCT、D-D水平明显高于生存组,差异有统计学意义（P〈0.05）。结论：CRP、PCT、D-D水平与CAP患者严重程度具有一定相关性,可作为判断病情、预测预后的重要指标,高水平CRP、PCT、D-D提示病情严重及预后不佳。Objective：To investigate the clinical significance of C- reactive protein （CRP）,calcitonin （PCT）and D- two （D-D）in community acquired pneumonia.Methods：A total of 102 patients with community-acquired pneumonia （CAP）admit-ted from March 201 5- March 201 6 as the research objects.A total of 5 mL peripheral venous blood of CAP patients （within 24 h of admission,before antibiotic therapy）were collected,and centrifuged to obtain serum.Immune turbidimetric method was used in determination of CRP and DD,immune fluorescence method was used for determination of PCT.Results：As grade in-creasing,the levels of CRP,PCT,D-D were increased gradually,with significant difference among different levels （P 〈 0. 05）;CRP,PCT and D-D levels of severe group were significantly higher than those of non severe group （P 〈 0.05）;death group,CRP,PCT and D-D levels of death group were significantly higher than those of the survival group （P 〈 0.05）.Conclu-sions：CRP,PCT,D-D levels have certain correlation with degree of severity.They can be used as important indicators to judge the severity of the disease,and predict the prognosis.High levels of CRP,PCT,D-D indicate severity of the disease and poor prognosis.

关 键 词：社区获得性肺炎 C反应蛋白 降钙素原 D-二聚体 

分 类 号：R575.2[医药卫生—消化系统]