替吉奥联合顺铂腹腔恒温循环热灌注治疗对胃癌合并腹水患者恶性分子表达的影响及毒副反应评估  

Effect of S-1 combined with cisplatin intraperitoneal circulatory hyperthermia perfusion treatment on malignant molecule expression in gastric cancer patients with ascites as well as side effect assessment

作　　者：简朔[1] 

机构地区：[1]四川省遂宁市中心医院肿瘤内科,四川遂宁629000

出　　处：《海南医学院学报》2016年第15期1730-1732,1736,共4页Journal of Hainan Medical University

基　　金：四川省卫生厅科研课题(130844)~~

摘　　要：目的:研究替吉奥联合顺铂腹腔恒温循环热灌注治疗对胃癌合并腹水患者恶性分子表达的影响及相关的毒副反应。方法:选择2012年2月~2015年7月期间四川省遂宁市中心医院收治的胃癌合并腹水患者作为研究对象,随机分为灌注化疗组和常规化疗组,比较两组患者的整体化疗情况、腹水FGF分子含量、外周血免疫功能指标以及毒副反应程度。结果:灌注化疗组患者的平均治疗周期多于常规化疗组,化疗两个周期内的腹水引流量显著少于常规化疗组;化疗后2个周期时,灌注化疗组患者的腹水bFGF、FGF-2、FGF19及FGFR4含量显著低于常规化疗组,外周血中CD3^+CD4^+、CD3^+CD56^+、CD3^-CD56^+的细胞含量高于常规化疗组,CD3^+CD8^+的细胞含量低于常规化疗组;化疗过程中,灌注化疗组患者发生白细胞计数减少、肝功能异常、肾功能异常、腹泻的例数显著低于常规化疗组。结论:替吉奥联合顺铂腹腔恒温循环热灌注化疗能够更为有效地提高治疗依从性、抑制腹水产生、杀伤胃癌细胞、改善免疫功能,且毒副反应较弱,是治疗胃癌合并腹水的理想方案。Objective：To study the effect of S-1 combined with cisplatin intraperitoneal circulatory hyperthermia perfu-sion on malignant molecule expression in gastric cancer patients with ascites as well as the related side effect.Methods：Gastric cancer patients with ascites who were treated in our hospital from February 2012 to July 201 5 were selected as research subjects and randomly divided into perfusion chemotherapy group and routine chemotherapy group,and then overall chemotherapy con-ditions,ascites FGF molecule content,peripheral blood immune function indexes and the degree of side effect were compared between two groups.Results：Average treatment cycles of perfusion chemotherapy group were more than those of routine chemotherapy group,and ascites drainage volume within two cycles of chemotherapy was significantly less than that of routine chemotherapy group;after two cycles of chemotherapy,bFGF,FGF-2,FGF1 9 and FGFR4 content in ascites of perfusion chemotherapy group were significantly lower than those of routine chemotherapy group,CD3 ＋ CD4 ＋ ,CD3 ＋ CD56 ＋ and CD3 -CD56 ＋ cell content in peripheral blood were higher than those of routine chemotherapy group,and CD3 ＋ CD8 ＋ cell content was lower than that of routine chemotherapy group;during chemotherapy,the number of cases with decreased numeration of leu-kocyte,abnormal liver function,abnormal kidney function and diarrhea of perfusion chemotherapy group were significantly lower than those of routine chemotherapy group.Conclusions：S-1 combined with cisplatin intraperitoneal circulatory hyperther-mia perfusion chemotherapy can more effectively improve treatment compliance,suppress ascites,kill gastric cancer cells and improve immune function.It has fewer side effect and is the ideal way to treat gastric cancer with ascites.

关 键 词：胃癌 替吉奥 顺铂 循环热灌注 腹水 成纤维细胞生长因子 毒副反应 

分 类 号：R735.2[医药卫生—肿瘤]