中西医结合疗法治疗溃疡性结肠炎对血小板、凝血功能及炎性因子的影响  

Effects of combined therapy of traditional Chinese medicine and western medicine on platelets,coagulative functions and inflammatory cytokines with ulcerative colitis

作　　者：雷云霞[1] 何磊[1] 盛好[1] 刘新[2] 

机构地区：[1]新疆医科大学附属中医医院脾胃病科,新疆乌鲁木齐830000 [2]新疆医科大学中医学院,新疆乌鲁木齐830011

出　　处：《海南医学院学报》2016年第14期1532-1534,1537,共4页Journal of Hainan Medical University

基　　金：新疆维吾尔自治区自然科学基金资助项目(2014152B092)~~

摘　　要：目的:探讨中西医结合疗法对溃疡性结肠炎患者血小板及相关参数、凝血功能及炎性因子水平的影响。方法:选取本院UC活动期患者共267例,分为观察组137例,给予中西医结合疗法治疗,对照组130例,给予单纯西药口服治疗,并分别检测两组治疗前后外周血血小板及相关参数、凝血功能及炎性因子的水平。结果:经不同方案治疗后,两组血小板计数(PLT)和血小板分布宽度(PDW)较治疗前均显著降低,平均血小板体积(MPV)显著升高(P<0.05),其中观察组的PLT及PDW显著低于对照组(P<0.05),MPV高于对照组,但差异无统计学意义(P>0.05);两组纤维蛋白原(Fib)和D-二聚体(DD)较治疗前均显著降低(P<0.05),其中观察组的Fib及DD显著低于对照组(P<0.05),部分活化凝血酶原时间(APTT)和凝血酶原时间(PT)在治疗前后及两组间比较,差异均无统计学意义(P>0.05);两组TNF-α、IL-6和IL-8均明显降低(P<0.05),其中观察组TNF-α、IL-6和IL-8均明显低于对照组(P<0.05)。结论:中西医结合疗法较单纯西药口服疗法更有效改善UC患者体内凝血和纤溶异常状态,同时具有强大的抗炎作用。Objective:To explore the effects of combined therapy of traditional Chinese medicine and western medicine on platelets,coagulative functions and inflammatory cytokines in patients with ulcerative colitis(UC).Methods:A total of 267 patients with UC were collected including 137 patients who were treated with combined therapy of traditional Chinese medicine and western medicine(experimental group)and 130 patients were treated with only western medicine(as controls).Platelet count,coagulation function indexes and inflammatory cytokines were measured before and 15 days after the treatment.Results:No significant differences were found in all indexes before treatment between two groups.After different treatments,plateletcount(PLT),platelet distribution width(PDW)were significantly decreased in both groups,but mean platelet volumn(MPV)were significantly increased than before treatment(P<0.05).PLT and PDW were significantly lower and MPV were significantly higher in experimental group than control group(P<0.05).Fibrinogen(Fib)and D-dimer(DD)decreased significantly after treatment(P<0.05).Fib and DD in experimental group were significantly lower than controls(P<0.05).No significant differences were found in activated partial thromboplastin time(APTT)and prothrobin time(PT)(P>0.05).Tumor necrosisi factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)decreased significantly in both group after treatment(P<0.05).TNF-α,IL-6and IL-8were significantly lower in experimental group than controls(P<0.05).Conclusion:Combined therapy of traditional Chinese medicine and western medicine can more effectively improve the cogulation,fibrinolysis and inflammation in patients with UC than western medicine alone.

关 键 词：溃疡性结肠炎 中西医结合疗法 血小板 凝血功能 炎性因子 

分 类 号：R574.62[医药卫生—消化系统]