Effect of Fish Oil on Left Ventricular Function in Anes-thetized Rats  

鱼油（EPA和DHA）对麻醉大鼠左室功能的影响

作　　者：张芳[1] 周建政[1] 吴葆杰 张岫美 

机构地区：[1]山东医科大学基础部药理学教研室,北京市军事医学科学院毒物药物研究所

出　　处：《Journal of Chinese Pharmaceutical Sciences》1996年第4期207-212,共6页中国药学（英文版）

摘　　要：The effect of fish oil on the basal left ventricular function and changes of left ventricular function induced by isoproterenol(ISO)were demonstrated in our study. The detennina-tion of cardiac perfonnance in vivo showed that supplementation with fish oil(EPA and DHA,70%,1.4 ml / kg) had no significant effect on basal cardiac perfonnance,while it could significantly inhibit changes of+ dp / dt_(max),V_(pm) and HR induced by ISO(0.4μg/ kg,4.0μg/ kg,40μg/ kg)intrave-nously.The results suggested that supplementation with fish oil perhaps affected the function of β-adrenoceptors on rat myocardial membrane.本文观察了鱼油对麻醉大鼠基础左室功能和异丙肾上腺素（ＩＳＯ）诱导的左室功能改变的影响。实验结果表明，鱼油（ＥＰＡ和ＤＨＡ，７０％，１．４ｍｌ／ｋｇ）摄入两周对大鼠基础心功能无显著影响，但可显著地抑制ＩＳＯ（０．４μｇ／ｋｇ，４．０μｇ／ｋｇ，４０μｇ／ｋｇ）诱导的正性肌力和正性频率作用，对ＩＳＯ诱导的心室前负荷的改变却大显著影响，结果提示鱼油的摄入可能影响大鼠心肌细胞膜上β－受体的功能。

关 键 词：Fish oil EPA and DHA Left ventricular function -ADRENOCEPTOR 

分 类 号：R972.6[医药卫生—药品]